IN PARTNERSHIP
in the chart on the opposite page, have shown digital monitoring to be 97% accurate, compared with 60% accurate for pill count; 50% for healthcare professional rating; and just 27% for self-report4
; and, crucially, that it can
improve adherence to medication by up to 50%. SMART packaging offers a compelling value proposition to empower and engage patients across drug development and trade.
Effective transitioning from clinical trials to trade: The GoodStart Program In the clinical trial setting, WestRock’s Electronic Dosepak® and Cerepak® solutions are ready for sponsors and contract research organisations (CROs) to implement through their contract manufacturing organisations. In commercial applications, WestRock’s
extensive experience in the design and implementation of adherence-focused packaging solutions, such as calendarised blister Dosepak® packages, has demonstrated that, once a habit of taking medication is established, patients tend to better adhere longer term. Towards that end, a GoodStart Program™ involves launching a drug in a SMART package for a period of 120 days to establish a baseline understanding of medication-taking behaviour. This initial period is followed by a seamless transition to the proven, non-electronic Dosepak® to maintain adherence results. As a partner, WestRock’s extensive
experience in market with a patient-centric approach to adherence in package design for both clinical and commercial applications – based on therapeutic focus, regimen and patient needs – establishes the foundation for the implementation of a SMART program.
WestRock and AARDEX Group: your knowledge and innovation partners While there is a huge surge of initiatives around digital adherence technologies, the use case, the value, and the path to implementation remains unclear. WestRock is a strategic partner of choice for brands, CROs and sponsors. WestRock can assist in navigating the uncharted SMART journey across clinical and trade, from internal stakeholder evaluation, UX studies, pilots, clinical trials and commercialisation. WestRock has taken a science-based approach in evolving a pharma adherence
84 | Outsourcing in Clinical Trials Handbook
“Poor adherence to dosing regimens can severely impact on data integrity and put patient safety at risk. It can lead to underestimates of drug power. By integrating AARDEX Group’s real- time adherence platform with WestRock’s SMART packaging, researchers have access to the intelligence to action timely interventions” Bernard Vrijens, CEO, AARDEX Group
packaging platform that improves patient 5, 6, 7
.
With the emerging landscape of DCT (decentralised trials), aligning with industry focus on digital transformation and patient empowerment is important. WestRock has electronically-enabled its proven, award-winning calendarised blister pack – the Dosepak®, to digitally capture dosing events. WestRock’s SMART Dosepak® variants Cerepak® and Electronic Dosepak® (EDP) are fully compatible with our partner AARDEX Group’s Medication Event Monitoring System (MEMS AS®) software. WestRock believes that improving medication adherence must be central to any successful digital health strategy and therapeutic pipeline. WestRock, in collaboration with AARDEX, offers SMART “turnkey” adherence-improving solutions to brands, sponsors and CROs.
For more information on WestRock’s healthcare packaging solutions, visit
westrock.com/ markets/healthcare.
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