Contents
the University of Oxford to find out how significant supply chains are in the journey to become carbon neutral.
27 Reimagine the pharma supply chain Controlant
28 Steady supply in a turbulent economy
The pharmaceutical industry pulled through during the height of the pandemic, despite increased lead times and delays to shipping. But given that these shocks to the supply chain are still being felt, some say the industry is now in the midst of a perfect storm. Andrea Valentino speaks to Maxine Fritz of NSF International, and Tacy Foster of McKinsey, to find out how the current economic and geopolitical landscape is impacting supply chains, how new technology is helping improve things and whether a transformation away from globalised networks is necessary.
31 The fight against pharma counterfeits SICPA
32 Protecting precious cargo Turkish Cargo
Chemicals & raw materials
33 The patient priority There’s a good reason that drug formulation is carried out by scientists with at least a master’s degree in chemistry; ingredients can be expensive for a start, but they also have to be balanced in a way that
achieves an end goal. For solid oral medications, this can mean the quick and sustained release of chemicals. For liquid forms it can mean attaining a viscosity proportional to the drug concentration. In both cases, the key is the use of excipients, and Mae Losasso speaks to Dr Shazia Bashir, teaching fellow in the School of Cancer and Pharmaceutical Sciences at King’s College London to find out how scientists use them to reach the right balance of ingredients for an effective drug.
37 Get the right dose SPI Pharma
39 The heart of pharma CPHI Frankfurt
Manufacturing
40 Automated creation In many cases, pharmaceutical
40 World Pharmaceutical Frontiers /
www.worldpharmaceuticals.net
production is a relatively hands-off affair, with specialised machinery carrying out much of the work that was once done by hand. But when it comes to products with live cells inside and the financial risk of them failing, automated production becomes a much more complex issue. That said, there are still companies trying to make automated cell and gene therapy production a reality; Michele Brailsford speaks to Dr Qasim Rafiq, associate professor of Cell and Gene Therapy Bioprocess Engineering at University College London, to discover some of the innovations that could help accelerate the manufacture of what many believe to be the next frontier in pharmaceutical medicine.
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43 Rotating sterilisation LAST Technology
45 Purification control technology at its best BEA Technologies
47 Understanding digital transformation in pharma Azion
49 Contamination control Dycem
50 3D printing: The future of pharmaceuticals DFE Pharma
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