Company insight
dissolve or mix well with water, blood and other body fluids, and are therefore unusable as medicine. In the pharmaceutical industry, they are usually dissolved in a “carrier” oil and, thanks to the use of a detergent, the oily solution is dispersed in water. Some others are instead encased in microscopic water- soluble particles. However, carrier oils and additives can have unpleasant side effects, trigger allergic reactions or be painful to inject, while the soluble-particle approach requires a complicated manufacturing process. Over the years, several techniques were used to improve the effectiveness, from an oil and water mix to the most recent water and hydrogel mixture, which
Rotating sterilisation M
any drugs are fat soluble chemicals that do not
are much less complicated formulations. Due to their consistency, these drugs are not easy to sterilise. They need to be kept moving throughout the entire sterilisation cycle and this is because the fluid they are made of would undoubtedly separate if allowed to remain static and heated.
Spinning around
Since it is important that the fluid inside the receptacles has to be kept constantly stirred all the time to prevent separation, a terminal steriliser provided with a rotating loading system is the optimal choice. Under usual circumstances and conditions, a sterilisation cycle in such terminal sterilisers requires the air to be removed inside the chamber. This is deemed to be a necessary step in order to establish a direct relationship between
The TS ROTO by LAST Technology is fitted with nozzles that distribute the superheated water spray throughout the chamber to ensure internal temperature uniformity during sterilisation.
pressure and temperature during the processing stage. However, by creating a vacuum inside the chamber with this particular load, it will cause an imbalance between the pressure inside and outside the product, and this will most likely leading to rupture of receptacle and loss of the product. The TS ROTO by LAST Technology in this case is fitted with nozzles that distribute the superheated water spray throughout the chamber so to ensure internal temperature uniformity. Back pressure air is appropriately regulated in the early stages of heating and in the cooling stages, according to the internal pressure of the receptacles. ●
www.lasttechnology.it
WPF042_LAST.indd 3 World Pharmaceutical Frontiers /
www.worldpharmaceuticals.net
01/08/2022 17:15 43
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