Drug delivery The human element
Self-managing a long-term illness can be a frustrating task, especially when that management involves routine injections. But injectables have come a long way since the humble syringe and the invention of the hypodermic needle. Debbie Orme speaks to Susan Neadle, president of Combination Products Consulting Services, about the evolution of injectable drug delivery, and how designing with the end customer in mind leads to better products.
hen French author, Jules Renard, said, “It’s not how old you are, but how you are old”, he could never have imagined the relevance of his words in the 21st century. As global populations continue to become increasingly geriatric, the incidence of conditions, such as diabetes, heart disease and chronic obstructive pulmonary disorder (COPD) continues to increase incrementally and, as incidences grow, the onus is falling on patients to self-manage their conditions. The Covid-19 pandemic has also forced healthcare systems globally to change care delivery models to ensure that they meet quality and access targets. Historically, self-management was centred around
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syringes and hypodermic needles. Syringes were used in the Roman era in the first century AD. Then, in the ninth century AD, an Egyptian surgeon created a syringe using a hollow glass tube and suction. Much later, in 1844, Francis Rynd is widely believed to have created the first hypodermic needle through annealing the edges of a folded flat strip of steel to make a tube, which was then drawn through gradually narrower dies. Fortunately, injectables have come a long way since then. Today, the most popular self-management systems are pre-filled syringes, pens, autoinjectors and connected information systems: the ultimate in a new generation of connected autoinjectors and other drug delivery technologies.
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World Pharmorld Pharmaceutical Frontiers /
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