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PHIL RAMSHEAD – BID MANAGER, BES VENTILATION


Meeting air flow and process efficiencyneeds


One of the UK’s leading biopharmaceutical companies has invested in ensuring it keeps pace with cancer treatment innovation and provides the highest standard of facilities in order to maintain quality standards, attract talent and embed staff wellbeing in the work environment.


Early cancer diagnosis, research and treatment have advanced exponentially in recent years, improving patient outcomes. As our understanding of cancer develops and treatments become increasingly sophisticated, there is a need to custom prepare medication to meet the specific needs of the patient and their condition. This, in turn, demands increasingly sophisticated production facilities, both in the pharmaceutical manufacturing sector and in hospital environments, where biopharma best practice can provide key learning for safe, effective and energy efficient drug preparation suites. One of the UK’s leading biopharmaceutical companies has invested in ensuring it keeps pace with cancer treatment innovation and provides the highest standard of facilities in order to maintain quality standards, attract talent and embed staff wellbeing in the work environment. One of its most recent asset development projects involved upgrading an existing production plant to a clean room and the addition of extra production capacity with the fit out of an adjacent redundant building. This project has increased capability for specialist processing in the manufacture of tailored cancer drugs. The remit included interrogating the


brief to ascertain where innovative ideas could add value to core concepts and deliver an upgrade to the existing facility


One of the corridors within the production facility.


based on a philosophy of continuous improvement. As a starting point for the design of the upgraded production environment, a survey of the existing facility was carried out, which revealed that fume cupboards were used at several points in the production process. The existing facility featured two purpose designed down-flow booths for a purification process that is business critical to the quality of the finished preparations.


Phil Ramshead


Phil Ramshead is bid manager for BES for whom he prepares high quality tenders and bid proposals. He joined the company as senior project manager in 2012, advancing to team leader before moving to his current role two years ago. Phil has


successfully managed the design and build of specialist facilities within the pharmaceutical industry and has been instrumental in the delivery of fit-out, HVAC, electrical and process systems for high profile and complex projects. His experience extends to the development of project execution, health and safety plans and


user requirement specifications for projects, through liaising with clients to interpret their requirements into proposal documents.


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The project Each down-flow booth contained purification flasks and a low temperature oven to slow bake the preparation to bespoke requirements. In each booth, conditioned air was fed in at the top and flowed down to low level extract points at the back of the booth, above the bench area for the flasks. It was noted that operator breathing zones were located close to fume generation points within these down-flow booths in the legacy facility. Down-flow booths are classed as partial enclosures and generally recognised as a reasonably effective means of fume control, with Health and Safety Executive (HSE) guidance referring to them as a “compromise between containment and accessibility”. However, the American Conference of Governmental Industrial Hygienists (ACGIH) ‘Industrial Ventilation: A manual of recommended practice’ recommends that air should be “designed to deliver airflow uniformly through the ceiling face and remove it uniformly from the floor”.


IFHE DIGEST 2019


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