Surgery
improvement. Blood loss can make a significant difference to those who entrust us with their care and safety. If innovative solutions exist, they can and should be embraced and adopted into practice with expediency.
CSJ
*Pre-clinical test data are not necessarily indicative of clinical performance
References 1. Trauma of major surgery: A global problem that is not going away available from https://
www.sciencedirect.com/science/article/pii/ S1743919120305525?via%3Dihub (accessed 08 Aug 2024)
2. Bannow BS, Konkle BA. How I approach bleeding in hospitalized patients. Blood. 2023;142(9):761-768
3. Raykar NP, Makin J, Khajanchi M, et al. Assessing the global burden of hemorrhage: The global blood supply, deficits, and potential solutions. SAGE Open Med. 2021;9.
4. Bizard F, et al. Medico-economic impact of enhanced rehabilitation after surgery: an exhaustive, nation-wide claims study. BMC Health Serv Res 2021;21:1341.
5. Ferko, A systematic approach to surgical hemostat use supports standardization and cost efficiencies. Healthcare Purchasing News; 2017;ePub;Nov 2017
6. Afolabi M, Johnston SS, Tewari P, Danker WA. Increasing Incremental Burden of Surgical Bleeding Associated with Multiple Comorbidities as Measured by the Elixhauser Comorbidity Index: A Retrospective Database Analysis. Med Devices (Auckl). 2023;16:237-24
7. Iannitti DA, Kim C, Ito D, Epstein J. Impact of an active hemostatic product treatment approach on bleeding-related complications and hospital costs among inpatient surgeries in the United States. J Med Econ. 2021 Jan-Dec;24(1):514-523
8. Johnston S, Afolabi M, Tewari, P, et al. Clinical and Economic Burden Associated with Disruptive Surgical Bleeding: A Retrospective Database Analysis. ClinicoEconomics and Outcomes Research 2023:15 535–547. doi:10.2147_CEOR.S411778
9. Corral, Health and economic outcomes associated with uncontrolled surgical bleeding: a retrospective analysis of the Premier Perspectives Database, Clinico Economics and Outcomes Research;2015;7;409
10. Shah PC, de Groot A, Cerfolio R, Huang WC, Huang K, Song C, Li Y, Kreaden U, Oh DS. Impact of type of minimally invasive approach on open conversions across ten common procedures in different specialties. Surg Endosc. 2022 Aug;36(8):6067-6075
11. Notarnicola A, Moretti L, Martucci A, Spinarelli A, Tafuri S, Pesce V, Moretti B. Comparative
70
www.clinicalservicesjournal.com I November 2024
efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty. Blood Coagul Fibrinolysis. 2012; 23 (4):278-284
12. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br. 2007; 89 (3):306-309
13. Sabatini L, Trecci A, Imarisio D, Uslenghi MD, Bianco G, Scagnelli R. Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty. J Orthop Traumatol. 2012; 13 (3):145-151
14. Wang GJ, Hungerford DS, Savory CG, Rosenberg AG, Mont MA, Burks SG, Mayers SL, Spotnitz WD. Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty: a brief note on a randomized prospective trial. J Bone Joint Surg. 2001. 83-A (10):1503-1505
15. Randelli F, Banci L, Ragone V, Pavesi M, Randelli G. Effectiveness of fibrin sealant after cementless total hip replacement: a double-blind randomized controlled trial. Int J Immunopathol Pharmacol. 2013; 26 (1):189-197
16. Joseph T, Adeosun A, Paes T, Bahal V. Randomised controlled trial to evaluate the efficacy of TachoComb H Patches in Controllin PTFE Suture–hole Bleeding. Eur J Vasc Endovasc Surg. 2004; 27, 549–552
17. Dancey AL, Cheema M, Thomas SS (2010) A prospective randomized trial of the efficacy of marginal quilting sutures and fibrin sealant in reducing the incidence of seromas in the extended latissimus dorsi donor site. Plast Reconstr Surg 125 (5):1309-1317
18. Ye X, Rupnow MF, Hammond J, Shah M, Farrelly E. Readmission rates and hospital costs associated with fibrin sealant use among patients undergoing orthopaedic surgery. J Orthopaedics. 2012;9 (1) e11
19. Ramirez GM, Castillo G, Ramirez AM. The economic burden of bleeds and transfusions in selected surgeries: a retrospective multi center analysis from the us perspective. AJBSR. 2019;2:211–215.
20. Johnson & Johnson MedTech. Surgical Bleeding Adjunctive Haemostasis Optimisation Program. Available at:
https://www.jnjmedtech.com/ en-EMEA/campaign/Surgical-Bleeding- Adjunctive-Haemostasis-Optimisation- Program. (Accessed 08 Aug 2024]
21. Guo Y, et al. Recent advances in the medical applications of hemostatic materials. Theranostics. 2023;13(1):161-196.
22. GATT Technologies BV, DHF-SR-120 Partly heparinized in vivo porcine model ORSI, Nov 2021, Data on File
23. GATT Technologies BV, DHF-SR-142 Partly
Walter A Danker III, Ph.D. is a Sr. Director, Global Health Economics & Market Access for J&J MedTech Surgery. He holds a Ph.D in Neuropharmacology and a Masters in Health Policy. He has over 25 years of experience with Johnson & Johnson, with the last 10 years focused on researching the burden of surgical complications and the cost effectiveness of a range of medical devices including adjunctive haemostats.
Gerard Llanos, Ph.D. is a Research Fellow in the Ethicon Surgical Technologies R&D group at J&J MedTech. He holds a PhD in Chemical Engineering from the University of Toronto. He has more than 32 years of experience in medical device R&D, developing and commercialising products ranging from ophthalmic implants, cardiovascular implants to advanced hemostats for addressing surgical site bleeding.
heparinized in vivo porcine model. Radboudumc. Jan 2023, Data on File
24. GATT Technologies BV, DHF-01-SR-152 - GATT- Patch vs Floseal in porcine kidney cavity bleeding, Jan 2022, Data on File
25. Orsi Academy, DHF-01-SR-154 GATT-Patch vs Suturing in a robotic porcine partial nephrectomy model, Feb 22, Data on File
26. GATT Technologies BV, DHF-01-QR-021 Clinical Investigation Report, Feb 2022, Data on File
w About the authors
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