published data shows that cows with systemic inflammation require on average 1kg of glucose more, during a 12-hour period, than cows without inflammation. The fact that the immune system is using primary glucose as an energy source, which is also needed by the mammary gland for milk production, leads to continuous immune depression and the prolongation of subacute systemic inflammation. An activated immune system around calving might be one of the primary triggers of NEB and subclinical ketosis. Research data demonstrates that reducing systemic inflammation immediately after calving may help promote faster metabolic adaptation and higher milk production. A dairy cow’s immune system is often altered dramatically during the transi- tion period. Immune changes often provoke systemic inflammation with- out any sign of infection. Inflammation is considered to be a major contributor to NEB, loss in milk production, and reproductive failure, due to high energy de- mands by the immune system to sustain the inflammation. It is generally accepted that subclinical ketosis leads to a reduc- tion in dry matter intake of 20%, with a consequent reduction in milk production of about 2 kg. Calculations by the Universi- ty of Toulouse and INRA show an economic loss of about € 210 per calving cow in cases of subclinical ketosis. Recently, however, it was proven that postpartum systemic inflamma- tion can be addressed by the provision of proper nutrition and the inclusion of certain probiotics in the diet.
Mitigating inflammatory markers The probiotic yeast Actisaf Sc 47, from Phileo by Lesaffre, is well known for its effect on preventing acidosis and for improving fibre digestion in lactating dairy cows. Latest studies show that Actisaf Sc 47 supplementation, given from -21 to +21 days from calving (DFC), is able to mitigate inflammatory markers after calving, and significantly reduce blood haptoglobin (Figure 1) and BHBA (Figure 2) levels. Beta- hydroxybutyrate (BHB) is an important indicator of ketosis with values exceeding 1.2 mmol/litre blood being internationally recognised as suggesting subclinical ketosis. A study from 2018, measured the effect of the probiotic yeast in transition cows when supplemented from -21 to +21 DFC. A significant reduction of BHB concentration in the blood was recorded 28 days after calving, reducing the risk for ketosis. Daily feed intake was also higher at 15.6kg dry matter in probiotic yeast group, throughout the trial period, versus 14.6kg dry matter for control group cows. Milk production
was consequently higher for supplemented group at 35.8kg/d compared to the control group’s 33.8kg/d.
Reducing the risk of milk fever Cows supplemented with the yeast probiotic during transition also had higher dry matter intake, higher milk production, and lost significantly less body condition. The increase in milk production could be explained by better rumen health, boosting energy supplies to lactating cows. Better rumen health could also explain significant improvements in the absorption and bioavailability of magnesium from 1-28 DFC. This safeguards animal health by decreasing the risk of paresis (milk fever). Study evidence of significantly lower concentrations of blood haptoglobin and BHB reflects the reduction of both lipomo- bilisation processes and hepatic ketogenesis, suggesting an improvement in energy balance, reduced systemic inflamma- tion, and a lowering of the risk of subclinical ketosis. The yeast probiotic supplementation during transition reduced haptoglobin and BHB levels in the blood. This helped ensure a smoother transition, lowering systemic inflammation and the risk of subclinical ketosis. Actisaf Sc 47 supplementation is proven to improve energy status and metabolism, hence increasing the supply of energy for milk production. Our depth of understanding of probiotic strains allows us to develop innovative nutritional solutions to mitigate the negative effects of postpartum inflammation and NEB in high producing dairy cows.
References are available from the author on request ▶ COW HEALTH | AUGUST 2020 27
Immediately after calving, energy demands increase at a faster rate than energy intake.
PHOTO: SHUTTERSTOCK
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