BIOTECH & LIFE SCIENCES
Advances in 3D imaging
A partnership between leading technology companies promises to provide a next generation multimodal imaging platform
The HT-X1 Plus offers high resolution 3D imaging and stability
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anufacturer of high- end microscopy solutions CrestOptics has partnered with a
leader in holotomography (HT) technology Tomocube to develop a next-generation multimodal imaging platform, the HT-X1 Plus.
WHAT IS IT FOR? By combining the expertise of both companies, this platform integrates CrestOptics’ spinning disk confocal technology with Tomocube’s latest HT innovation allowing users to leverage high-resolution, 3D holotomographic imaging alongside fl uorescence-based detection. This enables advanced and precise label-free biophysical imaging, according to a spokesperson for CrestOptics. The technique uses physics-based methods to study biological systems and the interactions between cells and molecules. It’s used to provide insight into living matter,
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which can help with disease treatment. It is therefore a powerful tool in life scientifi c research.
HIGH RESOLUTION 3D IMAGING AND STABILITY The HT-X1 Plus off ers high-resolution, 3D imaging and stability, according to CrestOptics. The platform is compatible with various imaging plates and powered by the TomoAnalysis software, which provides researchers with tools for detailed quantitative analysis and imaging across a wide range of applications.
IMAGING OF MULTILAYERED SPECIMENS The product provides imaging of multi-layered specimens with improved illumination optics and advanced image reconstruction algorithms. It uses a high-spec camera featuring a 4x larger fi eld of view and
signifi cantly reduced acquisition time than comparable products. It has been designed for use with high- throughput phenotypic screening of cells and organoids. The correlative imaging capabilities, incorporating an sCMOS-based fl uorescence module, enable integration of molecular studies with single-cell- resolution 3D images. The product extends the reach of
holotomography to a broad array of specimens, including dense organoids, tissue sections, and fast- moving microorganisms. The product enables acquisition of label-free, high-resolution 3D holotomography data and highly-sensitive, precise 3D fl uorescence data. Crest Optics’ product is the fi rst
commercially available spinning disc confocal holotomographic instrument enabling advanced 3D imaging with fl uorescent-based detection according to the company.
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