BIOTECH & LIFE SCIENCES
The enzymes developed can be used for the
sustainable manufacture of pharmaceuticals, including new therapeutic modalities
Designing enzymes from scratch could lead to an increase in the number of accesible reactions Similarly, the process is much less
computationally resource heavy than earlier methods of computational protein design making it less costly and time consuming. Lovelock says: ‘’Although the activity
of enzymes generated by computational methods may initially be lower than with natural enzymes, we can take advantage of the data generated to iteratively refine our design protocols, leading to improved success rates and higher catalytic efficiencies straight from the computer. Experimental engineering will remain an important aspect of the process in the short-medium term, but over time we hope to reduce the need for extensive experimental engineering campaigns.’’
OTHER BENEFITS As stated, the move from high- throughput experimental engineering of enzymes to a computational design process based on deep learning will save time and money. However, there are other key benefits according to Green. He explains that the findings will be shared widely via academic journals allowing more people in the field to carry out their own enzyme design campaigns. Over time the methods are likely to become more user friendly allowing non-specialists to work in the field and bring in new ideas. Green also expects that this will allow scientists like himself to devote their time to other aspects of their work.
NEW REACTIONS Designing enzymes from scratch could also lead to an increase in the number of reactions that are accessible to the field of biocatalysis. “Designing enzymes computationally will allow access to new types of chemistry that we wouldn’t be able to access otherwise,” Lovelock says. “In this way we will maximize the impact that biocatalysis can have on the development of a greener and more sustainable chemical industry.”
For more information visit:
www.mib.manchester.ac.uk
www.scientistlive.com 31
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