Microscopy & Microtechniques 43 Advanced AFM for effortless nanoscale imaging
ICSPI, a leader in benchtop nanoscale imaging instruments, unveils its latest innovation, the Redux AFM. This automated atomic force microscope (AFM) is designed to revolutionise nanoscale data collection, empowering scientists and engineers to effortlessly acquire 3-dimensional data with unprecedented ease.
With a mission to expand nanoscale measurement, ICSPI builds upon the success of its nGauge AFM, of which hundreds of units are in operation across over 30 countries. The Redux AFM represents a significant advancement, introducing automation to enhance the user experience of nanoscale imaging.
Traditional AFM instruments often suffer from complex and time-consuming setup processes, rooted in outdated technology from the 1980s. Recognising this challenge, ICSPI pioneered AFM-on-a-chip technology, which forms the foundation of the Redux AFM. By consolidating multiple components onto a single chip, the Redux streamlines nanoscale imaging, eliminating the complexities associated with traditional AFM setup.
Key features of the Redux AFM include: automated setup; laser-free alignment; high throughput; precision sample positioning; large sample platform.
David Morris, Director of Operations at ICSPI, explained: “Legacy AFMs, with their laser-based sensing and finicky silicon probes, are often daunting and time-consuming for users. Our goal with the Redux is to make AFM as fast and intuitive as optical microscopy, enabling scientists and engineers to focus on advancing scientific discovery and technological progress.”
Building on the success of the nGauge, the Redux introduces further automation, refining the user experience. Dr Nas Yousefi, Research Specialist at the nanoFAB, University of Alberta, commends the user-friendly design, highlighting the integrated optical microscope and motorised XY stage as valuable features for users.
ICSPI’s commitment to innovation has positioned its AFM instruments as essential tools for scientists, engineers, and educators worldwide. By simplifying complex processes and reducing data acquisition times, the Redux AFM opens new avenues for research and development across various fields.
More information online:
ilmt.co/PL/8xlp 62313pr@reply-direct.com High-resolution InGaAs camera with small pixels and low readout noise
The new C16741-40U InGaAs camera from Hamamatsu Photonics showcases an SXGA resolution of 1280 x 1024 pixels and an extended sensitivity range spanning from 400 nm to 1700 nm, encompassing both visible and short-wavelength infrared regions. Boasting 5 μm pixels, it excels in capturing high- resolution images with an exceptional signal-to-noise ratio, attributed to its minimised readout noise.
Furthermore, the camera integrates a Peltier element for efficient sensor cooling and temperature stabilisation. The USB 3.1 Gen 1 interface port facilitates 12-bit image acquisition and exposure time adjustment, contributing to its overall versatility and performance.
The key features of this new InGaAs Camera - high resolution, small pixel, and low readout noise significantly enhance the functionality of SWIR cameras across various applications from food and plastic sorting to silicon wafer inspection, laser beam alignment, and solar cell evaluation.
Any questions regarding the new InGaAs Camera C16741-40U, please contact Hamamatsu Photonics. More information online:
ilmt.co/PL/6Kpl
62153pr@reply-direct.com Unlocking high-resolution structural determination in cryo-TEM
Thermo Fisher Scientific introduces the Thermo Scientific Glacios 2 Cryo-TEM featuring the Low-Energy-Spread Cold Field Emission Source (E-CFEG). Initially designed for the company’s highest- powered 300kV cryo-transmission electron microscope (cryo-TEM), the E-CFEG is now also available for the 200kV Thermo Scientific Glacios 2 Cryo-TEM.
This expanded offering aims to enhance accessibility to cryo-electron microscopy (cryo-EM) techniques, providing boosted resolution while maintaining ease-of-use and productivity. The E-CFEG, known for its narrow energy spread supporting high-contrast images, enables near-atomic structural determination of complex proteins and macromolecules. This contributes to accelerated cryo-EM research and drug discovery processes, all achieved at a lower accelerating voltage.
In addition to advancing structural determination, the platform add-on simplifies workflows for users of varying experience levels in single particle analysis, cryo-electron tomography, and Micro-ED workflows. Equipped with AI-enabled algorithms for data collection and automated microscope alignments, it enhances ease of use and ensures consistently excellent data production.
Thermo Fisher Scientific’s recent data showcases the capability of this combination, generating a 1.5?Å resolution structure of Apoferritin. This achievement represents the highest resolution structure produced by a commercially available cryo-TEM operating at 200kV.
Key applications of the Glacios 2 Cryo-TEM with E-CFEG cater to structural biologists in biopharmaceutical and academic research. This solution is tailored for those seeking high-quality structural data with improved efficiency and ease of use.
More information online:
ilmt.co/PL/Lo7d 62120pr@reply-direct.com Live cell imaging at nanoscale resolution
Leica Microsystems unveils TauSTED Xtend, a groundbreaking advancement in STED microscopy. This innovative approach empowers extended multicolour live cell imaging at nanoscale resolution, providing scientists with unprecedented insights into dynamic biological processes.
By integrating spatial and lifetime information, TauSTED Xtend delivers detail of live or intact specimens at the nanoscale while minimising light exposure. This delicate balance ensures gentle imaging, enabling scientists to delve deeper into biological phenomena without compromising resolution.
James O’Brien, VP of Life Sciences and Applied Solutions at Leica Microsystems, affirmed: “TauSTED Xtend extends the duration of live cell experiments by offering a unique blend of light exposure and resolution, unlocking new dimensions in nanoscale exploration. Researchers can now uncover hidden intricacies in previously uncharted territories of research.”
TauSTED Xtend operates seamlessly in real-time, enabling researchers to observe rapid biological processes with nanoscale precision. This dynamic capability allows scientists to capture pivotal moments as they unfold, maximising the utility of their experimental observations.
Ulf Schwarz, Application Manager Confocal Microscopy at Leica Microsystems, highlighted: “TauSTED Xtend introduces novel possibilities for single- and multi-color experiments using green fluorescent proteins and fluorophores, essential tools in life science research. Leveraging familiar protocols and a wide array of fluorescent labels, scientists can now seamlessly transition their experiments to the nanoscale.”
Representing the pinnacle of stimulated emission depletion (STED) imaging, TauSTED Xtend revolutionises live-cell imaging with extended imaging times and unrivalled nanoscale resolution. Building upon Leica’s proprietary TauSTED approach developed in 2019, this latest innovation harnesses FLIM and lifetime-based technologies to elevate image quality and resolution.
When combined with the Leica STELLARIS 8 FALCON FLIM Microscope, TauSTED Xtend enables multi-fluorophore STED imaging with precise species separation based on fluorescence lifetime, opening new avenues for comprehensive nanoscale investigations.
More information online:
ilmt.co/PL/XO2Q 62312pr@reply-direct.com
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