32 Dual-labelled probes for real-time PCR
Biopharma assay developers and clinical research labs face the ongoing challenge of balancing efficiency, cost-effectiveness, and result accuracy. Multiplexing, or maximising the number of targets per sample, is a key strategy to achieve these goals. Thermo Fisher Scientific’s new Applied Biosystems™ TaqMan™ QSY2 probes facilitate this process by demonstrating improved assay performance retention during the transition from single-plex to six-plex assays. This advancement empowers researchers to develop multiplexed in-house assays faster, unlocking the full potential of their qPCR instruments.
The TaqMan QSY2 probes feature a novel quencher design that enhances signal-to-noise ratio and reduces background noise, particularly with TaqMan 5’ nuclease qPCR probes. Equipped with Cyanine 5 and Cyanine 5.5 long wavelength dyes, these probes allow for multiplexing in the far-red spectrum, enabling advanced target detection capabilities. Comparative studies have shown that TaqMan QSY and QSY2 probes outperform their counterparts, offering greater sensitivity, a broader dynamic range, and better performance retention when scaling from single-plex to six-plex assays.
Manufactured in ISO 13485 certified facilities, the new TaqMan QSY2 probes provide healthcare and biopharma assay developers with confidence in target detection, ensuring unmatched accuracy and reproducibility. Applications for these probes include microbial pathogen detection, monitoring impurities and fluctuations in bioproduction processes, and gene expression studies.
With features such as increased sensitivity, brighter signal production, and efficient scaling to multiplex assays, the TaqMan QSY and QSY2 probes enhance assay performance while optimising efficiency in assay development. Thermo Fisher’s commitment to providing accurate and reproducible results is further underscored by the availability of a full portfolio of dyes and quenchers for maximum assay design flexibility.
More information online:
ilmt.co/PL/G7MY 62442pr@reply-direct.com New process thermostats for demanding biotech and pharma applications
Lauda, a global leader in constant temperature equipment, introduces its latest product line - the Ultratemp process thermostats, tailored to meet the rigorous demands of biotechnological, biopharmaceutical, and industrial applications.
With heating and cooling outputs of 25 kW, 35 kW, or 50 kW, the Ultratemp devices are engineered to rapidly heat up or cool down large volumes. This capability proves invaluable for typical biotechnological, biopharmaceutical, and other industrial applications with diverse temperature and performance prerequisites.
The Ultratemp thermostats offer precise control over external consuming units within a range of -5°C to 60°C, maintaining a high temperature stability of ±0.5 K. This ensures accurate temperature control in various applications. The water-cooled refrigeration technology minimises heat discharge to the environment, and the use of non-flammable media, such as water or water-glycol, ensures straightforward handling and low operational costs.
These new Ultratemp process thermostats combine robustness with simplicity in operation. Standardised with protection level IP 54, they are shielded against splash water and are easy to clean, thanks to the high-quality stainless steel housing. Compatible with non-flammable temperature control media, the device is operated through function buttons and a clear LCD. The integrated Ethernet interface allows remote monitoring and control via a control station or PC. Moreover, external components like sensors (e.g., a Pt100 temperature probe) or signal transmitters can be connected.
The bi-frequency power supply (400 V; 3/PE; 50 Hz & 460 V; 3/PE; 60 Hz) equips the Ultratemp process thermostats for worldwide use. Additionally, they are available in an optimised design exclusively for 50 Hz. All variants can operate within an ambient temperature range of -15°C to 50°C.
The Ultratemp process thermostats expand Lauda’s product range, delivering optimal solutions for biotechnological applications with reactor volumes of up to 5,000 litres. Specially designed to meet the demands of the biopharmaceutical industry and its processes, these devices provide the necessary high heating and cooling capacities for extended process times at a constant temperature of 37°C, followed by rapid cooling of the reactor content.
With the introduction of Ultratemp process thermostats, Lauda strengthens its product portfolio, reaffirming its commitment to innovative temperature control solutions that enhance productivity and efficiency in biotechnology, pharmaceuticals, and industry worldwide.
More information online:
ilmt.co/PL/wzRR 62212pr@reply-direct.com Ultrasonic cleaning solutions for laboratory applications
The cavitation phenomenon consists of the formation and growth of millions of microscopic bubbles under a low-pressure stage, produced into the ultrasonic bath due to a high power transducer 40kHz. These bubbles break in all directions and attack every surface in contact with water, erasing dirt, impurities and pollutants when contacting with the materials or pieces into the bath. This phenomenon allows cleaning all kind of items without the need of disassembling, due to all the surfaces being in contact with the liquid. The heating function of the unit allows the acceleration of this cleaning process.
Wiggens presents two series of standard ultrasonic cleaners with reliable quality and useful features, which allows the users a wide range of cleaning applications such as lab materials, medical instruments, dental prosthesis, optics, industrial items, jewelleries, also the degasification or liquid dissolution and compact substances disaggregation.
The following are the standard working volumes supplied: 3, 6, 10 and 22 litres, and bespoke volumes can be ordered for different applications.
All functions can be viewed and monitored on a large and clear touch screen display. The parameters can be set by screen touching, including the ultrasonic working power (40% to 100%), bath temperature (20°C to 80°C), timer and warning function for safety.
All models are equipped with lids and trays that allow the parts they introduce to be directly cleaned without damaging the transducers and for easy handling.
In addition to the standard ultrasonic cleaners, Wiggens also offers the ultrasonic cleaners with special added functions. The Shaking Ultrasonic Cleaner is a good example, which means that the sample can be pre-homogenised at a specific shaking speed, and then final homogenisation can be achieved in a very short time, using ultrasonic power These two procedures can be carried out simultaneously or separately. Another added function is an ultrasonic cleaner with cooling for use in pathology and analysis labs, where the temperature of bath can be maintained at 10°C to 40°C even with the ultrasonic power generating heat continuously.
Contact Wiggens to accelerate your cleaning process. More information online:
ilmt.co/PL/9D59
Advanced custom CMOS image sensor development
Specialised Imaging Ltd announces SI Sensors, a new division dedicated to advanced CMOS image sensor development. With a team of specialists, SI Sensors creates custom designs with cutting-edge performance. Their expertise spans visible and non-visible imaging technologies, optimised light detection, charge transfer, and radiation-hard sensor design. Additionally, they pioneer novel imaging techniques such as ultra-fast burst mode imaging, utilising CCD-in-CMOS pixels.
Philip Brown, SI Sensors’ General Manager, highlighted their commitment to diverse sectors, including space and defence. Beyond developing sensors for Specialised Imaging’s ultra-fast cameras, they tailor solutions for unique design requirements. This includes bespoke sensor packages accommodating custom electrical, mechanical, and thermal interfaces. Their goal is to strike the optimal balance between sensor performance and cost, ensuring value for customers. Rigorous electro-optical testing, adhering to industry standards like EMVA 1288, guarantees consistent quality and reliability throughout production.
More information online:
ilmt.co/PL/kADO 62557pr@reply-direct.com
56962pr@reply-direct.com
LAB ASIA - JUNE 2024
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