Environmental Laboratory 21 Automated sample prep for streamlined chromatography


Tecan has introduced Resolvex Prep, an innovative mid-range benchtop automation solution tailored for chromatography sample preparation. This new instrument is poised to signifi cantly improve the effi ciency, precision, and dependability of chromatography sample preparation, bearing considerable relevance for analytical chemistry, proteomics, and applications within the fi eld of biomedical research.


Sample preparation for chromatography is a critical and technically intricate undertaking. Even slight variations can profoundly affect downstream assays. Through the automation of this process, laboratories can not only save valuable time and resources but also bolster the reliability of their outcomes.


Specifi cally designed for chromatography workfl ows, Resolvex Prep is ideally suited for LC-MS sample preparation. It offers the capability to process a wide range of batch sizes, spanning from fi ve to 100 samples. As such, it is particularly well-suited to medium-throughput laboratories. Moreover, it presents a cost-effective solution for enhancing both productivity and sample quality.


Resolvex Prep effectively addresses numerous challenges associated with chromatography sample preparation. By employing direct displacement pipetting, it mitigates the risks connected with volatile solvents. Additionally, it accommodates sealed sample tubes to prevent evaporation during processing. Notably, this automated system contributes to mitigating the existing shortage of trained laboratory personnel and is in compliance with chain of custody requirements.


A distinctive feature of Resolvex Prep is its fusion of high-quality, precision-engineered hardware with user-centric software characterised by its user-friendliness. The system can be mastered in less than an hour, and its robust yet adaptable confi guration streamlines effi ciency while minimising the potential for human error, ultimately resulting in precise and dependable outcomes.


Luca Valeggia, Senior Vice President of Lab Automation at Tecan, remarked: “We’re very pleased to be launching this new instrument. Bringing automation to the critical task of LC-MS sample prep will accelerate progress in a whole range of applications, from MS-based proteomics to biologics quality control, as well as food and environmental testing. It’s another contribution Tecan is making to help scale healthcare innovation globally.”


The versatility of Resolvex Prep makes it an invaluable addition to analytical laboratories across various domains, including pharmaceuticals, environmental sciences, food and beverage, forensics, and quality control processes.


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Real-time measurement of PFAS with Proton-Transfer-Reaction Mass Spectrometry (PTR-TOFMS)


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Perfl uorotributylamine or PFTBA (C12 concentration of 980 pptv in an N2 reactions of H3


The detection and quantifi cation of Poly- and Perfl uoroalkyl Substances (PFAS) has recently become one of the hottest topics in analytical chemistry. Many of these omnipresent “forever chemicals” are connected to serious health concerns and thus have been subject to increasingly stringent restrictions. So far, the vast majority of analytical PFAS studies have been performed offl ine, utilising time-consuming GC and LC based techniques. While these methods may be the gold standard for spot sampling, they render online compound monitoring impossible.


Ionicon recently presented the fi rst results of a comprehensive series of real-time direct- injection PTR-MS studies on PFAS: fi ndings on the ion chemistry, experimentally determined Limits-of-Detection (LoDs), and a proof-of-concept indoor air study. Ionicon utilised an


off-the-shelf PTR-TOF 6000 with a mass resolution of about 6000 m/∆m and a sensitivity of about 2000 cps/ppbv. As all Ionicon PTR-TOFMS instruments come with TRU-E/N®


O+ with PFTBA result in a product ion at m/z 413.977 (C8


N) is the most potent greenhouse gas known so far. It is available as a gas standard at a certifi ed matrix and was dynamically diluted to determine the Limits-of-Detection (LoDs). Dissociative PTR +). The high sensitivity of the PTR-TOF 6000 in combination


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with the extremely broad transmission range of IONICON’s hexapole ion guides and the low chemical background in this high mass region result in excellent LoDs: 2.4 pptv after only 1 s of integration time and 280 ppqv with 1 min integration time. With NO+ and NH4


via Ionicon’s patented ammonia-free method) reagent ions no PFTBA product ions can be observed. O2 charge transfer to product ions at m/z 501.971 (C9


NF20 A petri dish wetted with Perfl uorooctanol, an FTOH (C8 H5


+) and m/z 263.978 (C5 F13


NF10 +). O), was used to create an initial indoor air concentration of 6.7 ppbv in an offi ce


room of about 30 m³ (LxWxH: 410x250x290 cm; RT: 23-26°C; two walls consisting of windows) with low ventilation. 8.8 min after the start of the experiment the petri dish was removed. Subsequently, the indoor air was monitored for 48 hours at an increased integration time (set from initially 1 s to 30 s). 20 minutes into the experiment the measured concentration dropped to 50% and about 5 hours later to 10% of the initial 6.7 pptv. Interestingly, 24 hours after the start direct sunlight warmed the surfaces in the room, which caused an instant concentration increase by a factor of 2.3. Opening the windows for a short time and thus venting the room after 48 hours resulted in only a short dip in FTOH concentration, with 85 pptv being present after 63 hours. This is still fi ve times higher than the already elevated (due to previous experiments) background of 17 pptv at the beginning of the experiment.


In parallel to FTOH, perfl uorobutanoic or PFBA (C4 HF7 O2 ) was also released into indoor air using a wetted petri dish. PFBA is of particular interest


as this compound is known to accumulate in the lungs and increased plasma levels are associated with a greater severity of COVID-19 prognosis. However, in contrast to FTOH, indoor air concentration of PFBA dropped to 50% of the initial 676 pptv already after 10 minutes and to 10% after 25 minutes. 2 hours into the experiment the concentration was below 10 pptv and did not increase when the sun was heating up the room.


These three examples demonstrated the excellent performance of IONICON’s PTR-TOF 6000 for real-time quantifi cation of PFAS in air. Additionally, an in-depth study on a much wider range of PFAS will soon be published. For rare cases where the PTR-TOF 6000’s performance should still be insuffi cient, Ionicon recommends their brand-new FUSION PTR-TOF 10k with 20-40 times higher sensitivity and about twice the mass resolution. This Next-Gen PTR-TOF comes with the novel Fast-SRI ion source for nearly instant reagent ion switching and the ultra-clean FUSION reaction chamber for LoD’s <200 ppqv. This instrument is TRU-E/N certifi ed.


New automated single shot mercury analyser


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Given the ease of use and cost effectiveness, the system is also ideal for use out in the fi eld or off-shore on oil platforms. Systems can be calibrated in the lab/ on-shore prior to shipment, also meaning that hazardous mercury does not need to be shipped with the system. Maintenance is simple, with support often performed remotely, ideal when up-time is crucial.


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The new Milestone DMA-1 evo Direct Mercury Analyser from Analytix overcomes common sampling and calibration problems. The calibration can last up to six months and is matrix independent. Samples require no sample preparation and are simply weighted into either quartz or metal sample boats that are automatically loaded into the instrument. Measurements take as little as six minutes and total mercury results are generated at the end of analysis.


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+ (produced + reagent ions react via dissociative


ion chemistry, also for this feasibility study no compound-specifi c calibration is necessary for quantifi cation. F27


AccuStandard’s 3rd edition of their Total Petroleum Hydrocarbon Pattern Recognition Standards Booklet, Comprehensive Source of Pattern Recognition Standards for ASTM, EPA, AOAC Total Petroleum Hydrocarbon Methods, is now available. This resource assists analysts in accurately identifying contaminated samples from petrochemical spills and/or leaks by comparing their chromatographic profi les with known petroleum products.


To help analysts with establishing boiling ranges and identifying chromatographic patterns, this edition contains a compilation of petroleum product standards updated with overlayed chromatograms for nalkane window defi ning mixes TPH-LOW-01 (C8 to C20), TPH-MID-01 (C8 to C30) and DRH-008S-R2 (C8 to C40).


This updated edition also includes new chromatograms for renewable diesel fuel, aviation fuel, biodiesel 100 (B100) and motor oils SAE 5W30, 10W30 and 10W40.


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Free download of Total Petroleum Hydrocarbon (TPH) booklet


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