New book available soon from ILM Publications Analysis of
Oligonucleotides and their Related Substances
Edited by George Okafo, David Elder and Mike Webb
Over the last two decades, there has been significant growth in research and development of oligonucleotides as therapeutic medicines and diagnostic tools in the pharmaceutical and biotechnology industries. Oligonucleotide-based therapies are in development for cancer, respiratory and inflammatory disorders, cardiovascular disease, neurological disorders and rare diseases, particularly, where the disease has a genetic basis or origin. This book, Analysis of Oligonucleotides and Their related Substances, serves as an invaluable reference guide for scientists wanting to develop analytical strategies for this important and unique class of compound.
This book assembles an international panel of experts in the field of oligonucleotides chemistry to critically review the most up-to-date analytical strategies for synthetic oligonucleotides. The authors have collaborated to provide essential guidance on tried- and –tested approaches for characterising these biopolymers. Moreover, each contributor has provided some expert commentary on future analytical trends and perspectives that are likely to impact this field. Uniquely, this book focuses only on analytical methods that can be specifically tailored for oligonucleotides, while, other methods that can also be generically applied to small molecules with minimal changes have been deliberately excluded.
The book starts by introducing synthetic oligonucleotides in the context of their growing importance in the pharmaceutical and biotechnology industries as therapeutic medicines. The next chapter discusses the importance of characterising impurities and related substances in oligonucleotides, the different chemical classes and their synthetic origins. The following chapters then focus on current analytical methodologies and strategies for characterising synthetic oligonucleotides using modern separation sciences techniques, mass spectrometric and NMR approaches and thermal methods. In each chapter, the authors highlight how these techniques have been adapted for these biopolymers, discuss method development approaches and recommendations and provide numerous examples of how these methods have been applied to therapeutic and diagnostic oligonucleotides. Finally, the book concludes with a chapter describing degradation and stability considerations for oligonucleotides to help scientists understand how they degrade, what products are formed and analytical approaches.
In summary, Analysis of Oligonucleotides and Their related Substances serves to ensure that analytical chemists have access to a comprehensive and current scientific review of the scientific literature for characterising synthetic oligonucleotides and their related substances and real-life examples of how these methods have been applied.
ISBN: 9781906799144
Order this book at:
www.ilmpublications.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60
