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May Reduce Alzheimer’s Risk


A Modified Keto Diet


role in cognitive decline A 2020 study by researchers at Wake Forest School of


Y


Medicine revealed that following a modified ketogenic diet can help patients with mild cognitive impairment effectively reduce their risk of Alzheimer's disease. Published in the online journal EBioMedicine, the study has shone a spotlight on the link between your gut mycobiome, or fungal microbiome, and your risk factors for ongoing cognitive decline.


Fungi are a fundamental part of the human microbiome, the


collective array of microbes on and within your body. Early stud- ies into the mycobiome show that interactions between fungi, other microbes and their human hosts play a vital role in health and disease pathology. Like the greater microbiome, the myco- biome is directly affected by lifestyle choices, including what you eat and drink. As research into the microbiome deepens, scientists are


beginning to analyze the mycobiome for specific insights into its potential impacts on mental health.


Cognitive Decline Linked to Gut Microbiome


Prior scientific studies have reported that patients with mild


cognitive impairment (MCI), dementia and Alzheimer's disease (AD) exhibited an altered gut microbiome.


Dr. Susan Sykes, DC


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ou've probably heard about the microbiome, but what about the myco-biome? You play host to trillions of bac- teria, but it turns out the fungi in your gut may also play a


The research team at Wake Forest School of Medicine, led


by Hariom Yadav, assistant professor of molecular medicine, sought to expand on this field of inquiry by analyzing the distinct gut mycobiome signatures in patients with MCI, along with po- tential interactions of these signatures with diet and gut bacteria, and how those interactions may impact biomarkers for Alzheim- er's.


The research team's prior studies on a modified Mediterra- nean ketogenic diet (MMKD) demonstrated that eating a diet low in carbohydrates and high in protein and fats, from sources such as olive oil, avocados and seafood, improves AD biomarkers in cerebrospinal fluid and the signatures of gut bacteria. In this study, the focus was narrowed to the MMKD's impact on gut fungi in relation to disease pathology for MCI and AD.


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