Alpha Lipoic Acid (ALA): ALA is an antioxidant that a healthy


body normally makes. As a dietary supplement, lab and human research has proven its ability to: (1) block the oxidative damage caused by ischemia (inadequate blood supply) and reperfusion (the restoring of blood flow following injury), which commonly cause acute kidney failure; (2) prevent or mitigate against drug- induced kidney damage; and (3) improve diabetic renal function by lowering sugar levels and reducing OS. It is noteworthy, how- ever, that not all researchers agree on the beneficial impact of ALA supplementation on OS, inflammation, and red blood production in dialysis patients.


Vitamin B6 (especially as P5P or Pyridoxamine): Animal


studies have established that this member of the B complex family combats: (1) advanced glycation end products (AGEs), proteins or fats that are damaged and become harmful when combined with sugar, and advanced lipoxidation end-products (ALEs), both proven to greatly damage the kidneys; (2) high blood pressure; (3) diabetic nephropathy; (4) increase in creatinine in blood plasma; and (5) abnormal levels of excretion of urinary protein and albu- min.


CoEnzyme Q10 (CoQ10): This antioxidant, critical to the formation of cellular energy (ATP) and mitochondrial metabolism, is found in high levels in the kidneys, heart, and liver. Human studies have shown that CoQ10 concentration in the plasma of CKD patients is depressed, and research indicates that its supple- mentation can decrease OS, improve mitochondrial function, and


reduce adverse cardiovascular events in both dialysis and non-di- alysis kidney patients. Animal studies have also shown that CoQ10 can protect kidney tissue from numerous nephrotoxic drugs.


Other dietary supplements deemed to support optimal kidney function include: (1) omega-3 fatty acids/fish oil (anti-inflamma- tory); (2) vitamins E (especially Gamma E) and C (antioxidants); (3) resveratrol (antioxidant; anti-inflammatory); (4) vitamin D3 (antioxidant/OS inhibitor) (5) N-acetyl cysteine (NAC)(antioxidant/ OS inhibitor; replenishes glutathione stores; anti-inflammatory); (6) curcumin (from turmeric)(antioxidant; anti-inflammatory); and (7) chanca piedra (for kidney stones; increases excretion of magne- sium, potassium; decreases urinary oxalate and uric acid).


The statements in this article have not been evalu- ated by the Food and Drug Administration, are for educational purposes only, and are not intended to take the place of a physician’s advice. Submitted by Erika Dworkin, Board Certified in Holistic Nutrition®, Owner of the Manchester Parkade Health Shoppe


(860.646.8178), 378 Middle Turnpike West, Manchester, CT, www.cthealthshop.com), nutrition specialists trusted since 1956. Erika is available for consultation and to speak to groups, including on Zoom. All statements in this article are practice- or scientific evidence-based and references are available upon request. See ad below and on page 9.


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