10/ SEPTEMBER 2020 THE RIDER Cryopreservation of Equine Stem Cells for Cartilage Repair
Guelph, ON July, 22, 2020 - Cry- opreservation is the next exciting stage of research in stem cell therapy. Dr. Thomas Koch and his team are working to preserve cartilage chips for long-term stor- age, which would enable off-the- shelf use to treat localized cartilage defects. Defects that very often shorten or end horses athletic careers.
fication) is the formation of a solid from an aqueous solution without the formation of ice crys- tals. Using cartilage chips created from equine umbilical cord blood, this next stage in research has the potential to change the way cartilage defects are treated. If cryopreserved, stored
Cryopreservation (or vitri-
would be very efficient, with no need to harvest stem cells from the patient. This means fewer vis- its, less waiting and faster treat- ment.
cells can be used; treatment
video where Dr. Koch discusses the future of this ground-break- ing research, targeting a common issue (cartilage defects) across disciplines and even species
Listen to the following
preliminary study will allow for future funding sources from both equine specific and human med- icine.”
College is currently working in collaboration with a world- renown cartilage vitrification specialist, Dr. Jomha Nadr, and his team at the University of Al- berta, Edmonton to establish a ro- bust vitrification protocol for eCB-MSC-derived neocartilage. The work will generate pivotal data to support the clinical eval- uation of cryopreserved allogenic
The Ontario Veterinary
from Ontario Equestrian allowed for a preliminary study to find out if they were able to vitrify equine cartilage stem cells well from cadavers. “We are very ex- cited to have received this sup- port,”
says Koch. “The
(horse/human). An injection of funding
therapies are exciting, and the po- tential applications are wide ranging, from treating cartilage defects to potentially delaying the onset of osteo-arthritic changes to treating bacterial in- fections and inflammation. “We believe this work has the long- term potential to benefit both horses and humans through the development of novel off-the- shelf cell-based therapies for
implemented, this therapy would provide a safe, efficacious, and technically simple treatment for horses as well as provide an op- portunity for a Canadian biotech- nology business to bank and distribute vitrified cartilage tissue in unlimited quantities to the world market. The future of regenerative
eCBMSC cartilage chips to re- pair focal cartilage defects in re- search
horses. Fully
damaged joint cartilage,” says Koch.
www.equineguelph.ca. Story by: Jackie Bellamy-Zions
https://youtu.be/RZ10MG5-rb4
owners’ and care givers’ Centre at the University of Guelph in Canada. It is a unique partnership dedicated to the health and well- being of horses, supported and overseen by equine industry groups. Equine Guelph is the epi- centre for academia, industry and government - for the good of the equine industry as a whole. For further
information, visit
Check out Regenerative stem cell therapy - Dr Thomas Koch, Re- searcher
-
About Equine Guelph: Equine Guelph is the horse
Eastern Equine Encephalitis Confirmed in One Horse – United Counties of Leeds and Grenville
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I'll watch you and your horse working as a team, with some practical, do-able suggestions, based on equitation science.
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www.lindsaygriceridingcoach.com Secretary: Kit Bartle Kelly Lehman
Melanie Gray Shari Irwin
(519) 440-5941 (519) 807-2660 (519) 732-0263
On August 26, 2020, the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA) was notified of a confirmed case of eastern equine encephalitis (EEE) in a pony located in the United Counties of Leeds and Grenville. The unvaccinated pony was eutha- nized following the sudden onset and progres- sion of neurological signs. Laboratory diagnostic testing confirmed infection with the EEE virus (EEEv). EEE is not transmissible from horses to
people. Birds are the natural hosts for EEEv, which is transmitted to horses and humans by mosquitoes which have bitten an infected bird. Effective equine vaccines for EEE are
available and veterinarians should encourage clients to keep their horse’s vaccinations cur- rent. Once clinical infection develops, treat- ment options are limited to supportive care. The mortality rate in unvaccinated horses is high.
Veterinarians in Ontario should consider
EEE as a differential diagnosis in horses ex- hibiting neurological signs and can identify positive cases through appropriate testing. IgM antibodies to the EEEv can be detected in serum from horses with neurological signs. As
2020 Judges Committee (519) 372-2527
email:
melaniegraylifecoach@gmail.com email:
shari_irwin@hotmail.com email:
maddavery@gmail.com email:
drumbolady@hotmail.ca
Website:
www.whao.org Celebrating 67 Years! 2020 Sr. Judges
Cally Jo Fritz 21 Taylor Blvd., Elliot Lake, ON P5A 3H5 H: (226) 289-8563, C: (519) 280-8169 Email:
callygene@gmail.com
Melanie Gray 202011 Hwy 21, Owen Sound, ON N4K 5N7 (519) 372-2527,
melaniegraylifecoach@gmail.com
Shari Irwin 166 Gleasons Corner Road, Castleton, ON K0K 1M0. (905) 349-1092, Cell (905) 440-5941
shari_irwin@hotmail.com
Jamie Kuhl 899 10th St. W., Owen Sound, ON N4K 3S3. H: (226) 909-1447. C: (647) 290-6093 jamie@archlines .ca
Kelly Lehman 895893 Oxford Rd. 3,, Drumbo, ON N0J 1G0
C: (519) 807-2660. E:
maddavery@gmail.com Anne Marinacci 65 Swayze Court, Smithville, ON L0R 2A0 905-957-5619
Janet McClure 14156 Ten Mile Road R.R. #3, Ilderton, ON N0M 2A0 (519) 666-2482
janetmcclure1@gmail.com
janetmcclure1@gmail.com
Tom Saul 574 Valentina St., Petrolia, ON N0N 1R0 (519) 882-0958
tbsaul@outlook.com
Megan Sheppard 38 Rye Road, South River, ON P0A 1X0 (705) 492-2565, Cell (705) 492-2565
megandallaire@gmail.com
Kris Simpson 711 Middletown Rd., RR #2, Waterdown, ON L8B 1P7 (519) 831-7922
richlandshowhorses@gmail.com
Don Stauffer 9626 Wellington Rd. 14, P.O. Box 16, Conn, ON N0G 1N0 (226) 258-9206, Cell (519) 604-8864
thestauffers48@gmail.com
Robyn Storey 6-120 Dudhope Ave., Cambridge, ON N1R 4T7 (519) 620-9015, Cell: (519) 841-3934,
gatorrocks@hotmail.com
Brenda Thompson 284 Whitmore Dr., Waterloo, ON N2K 2N5 (519) 884-4050, Cell (519) 577-7320
bmctearnen@yahoo.ca
Mike Tucker 1581 Maple St. N., R.R. #4, Fenwick, ON L0S 1C0 (905) 892-5610, Cell (905) 984-1581
m.tucker@hotmail.ca
Jr. Judges
Dave Black 94 Concession 4 Road, Fisherville, ON N0A 1G0 C: 905 921 0359 Email:
diamondbquarterhorses@gmail.com
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Lorie Duff 7651 County Rd. 10, Vankleek Hill, ON K0B 1R0 H; 613 867-0776, C: 613 867 0776 Email:
dufflorie@yahoo.com
Erin Fawcett 9 Strong Court, Brantford, ON N3R 7Y4 C: (519) 754-3526, H: (519) 753-0757 Email:
efawcett78@hotmail.com
Erin O’Drowsky 253 James St. N., St. Mary’s, ON N4X 1A5 H: (519) 284-0684, C: (226) 377-0244 Email:
eodrowsk@gmail.com
Inactive Judges John Ward
well, RT-PCR testing can be performed on brain tissue if available. Clinical signs of EEE, including circling,
head-pressing, ataxia and depression, can mimic a variety of encephalitides, including rabies, West Nile virus (WNV), botulism, he- patic encephalopathy, equine protozoal myeloencephalitis, and equine herpes myeloencephalopathy. Most equine cases of EEE in Ontario occur between the months of August and October and end with the onset of frost. . EEEv affects mainly equine species in eastern North America but can rarely cause se- vere disease in humans. EEEv has also caused fatal infections in pheasants, quail, emus, al- pacas, llamas and dogs. EEEv has been reported in horses in On-
tario since 1938. Equine neurological cases are posted on the OMAFRA website at:
http://www.omafra.gov.on.ca/english/live- stock/horses/
westnile.htm
Ontario’s local public health units are
conducting mosquito surveillance for WNV and will report EEEv if found. Birds are the natural hosts for both viruses, which are trans- mitted to horses and humans by mosquitoes which have bitten an infected bird. As of Au- gust 15, 2020, no mosquito pools have tested positive for EEEv.
Agricultural Information Contact Centre 1-877-424-1300 E-mail :
ag.info.omafra@
ontario.ca www.ontario.ca/omafra www.publichealthontario.ca/en/DataAndAna- lytics/Pages/
WNV.aspx Questions about EEE in horses can be di- rected to: Dr. Alison Moore Lead Veterinarian – Animal Health and Welfare Ontario Ministry of Agriculture and Food Tel: (226) 821-0364 E-mail:
alison.moore@
ontario.ca
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