in-cos Cat 30/3/09 17:58 Page 56
56 Advertorial
Long-lasting beauty and healthy
skin are substantial clues to the
quality of life for most people
Reinforcing the skin’s
innate immunity
People with dermatological problems often feel uncomfortable in their own highly effective in killing Gram-negative bacteria and yeasts and has a
skin and are concerned not only by the formation of wrinkles, but also by bacteriostatic effect on Gram-positive bacteria, whereas human ß-defensin-
the appearance of redness, infections and acne scaring. 3 (hBD-3) is found to be a powerful peptide antibiotic exhibiting a broad
Lipotec introduces a new approach based on Molecular Cosmetics to spectrum of antimicrobial activity against various Gram-negative and Gram-
reinforce the skin’s natural defence mechanism, keeping the intricate positive bacteria as well as fungi at low micromolar concentrations.
balance that characterises perfect and healthy skin.
The search for a new Molecular Cosmetic active to
The natural response against microbial infections enhance the skin's natural defence system
The stratum corneum is the skin’s first protective barrier against external Defensins are one of the key components of the skin’s innate immune
forces and acts as a physical barrier to avoid invasion by exogenous system. Bodyfensine
™
is a new tripeptide able to stimulate ß-defensin
microbial agents. Normal human skin is colonised by large numbers of expression to expand our innate epithelial shield and avoid microbial
microorganisms, most of which live harmlessly as commensals without aggression. By keeping good levels of our natural antimicrobial skin
causing clinical disease. In addition to the normal skin flora, the skin is proteins, Bodyfensine
™
lowers the risk of possible infections by external
constantly challenged by pathogens. The physical barrier provided by the agents, such as in acne-prone skin. This new cosmetic active has been
epidermis is essential, but many microbes have evolved effective systems to created to keep skin constantly maintained, protected and healthy.
breach the epidermis. However, infection of normal healthy skin rarely The design of the new peptide was made through a combinatorial
occurs, suggesting that skin has an innate ability to fight invading microbes. chemistry approach and a high-throughput screening assay.
Human skin produces small peptides with antimicrobial activity that A combinatorial library of synthetic tripeptides was screened by using the
contribute to the resistance of the skin to invasion by microorganisms. The luciferase-based reporter gene assay, to identify potential hBD-2 boosters.
production of antimicrobial peptides (AMPs) has been shown to be essential Bodyfensine
™
was the best hBD-2 activator after two rounds of screening.
for normal defence against microbial infection, providing a rapid, first-line After that, the efficacy of the candidate was validated at both the
chemical barrier to inhibit microbial growth. AMPs are found in both plant transcriptional and translational level. Bodyfensine
™
proved to increase hBD-
and animal kingdoms, with a broad spectrum activity against bacteria, fungi, 2 mRNA relative levels by 26 per cent in a culture of human keratinocytes,
and viruses, where they are regarded as key elements of innate immunity. and also induced a 26 per cent and 10 per cent increase of the secreted
The AMPs produced in human skin include the subclass of defensins, hBD-2 and hBD-3 proteins respectively in human keratinocytes.
which are expressed in keratinocytes in skin. Mammalian defensins can be
subdivided in three more subfamilies, where the ß-defensins subfamily is For further information, please contact;
commercial@lipotec.com
characteristic of epithelial tissues. Expression and function of four ß-
www.lipotec.com
defensins (hBD-1 to -4) are well characterised. Human ß-defensin-2 is Lipotec S.A., Stand A300
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