AL a
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b New Products include:
• Tetradecabromodiphenoxybenzene metabolites
Figure 6 – a) Separation of the active ingredients in Tylenol Severe Allergy Maximum Strength Nighttime: 1) acetaminophen, 2) pseudoephedrine; 3) diphenhydramine. Column: Primesep 200, 3.2 × 100 mm; mobile phase: MeCN 5–50% in 5 min with 4-min hold, H2
SO4 0.03–0.2% in 5 min with
4-min hold; flow rate: 0.6 mL/min; detection: 270 nm; sample prepara- tion: 1 mg/mL in 1:1 MeCN:water. b) High-resolution separation of the active ingredients in Children’s Mucinex Multi-Symptom Cold Nighttime: 1) acetaminophen, 2) phenylephrine, 3) diphenhydramine. Column: Primesep 200, 3.2 × 100 mm; mobile phase: MeCN 5–50% in 5 min with 4-min hold, H3
PO4 0.05–0.3% in 5 min with 4-min hold; flow rate: 0.6 mL/
min; detection: 270 nm; sample preparation: 1 mg/mL in 1:1 MeCN:water. Future directions
Currently under development is a universal platform for the screening of drugs, metabolites, contaminants and other compounds. A priority will be to minimize the number of columns and mobile phase combinations.
References
1. Drug residues and microbial contamination in food: monitoring and enforcement. In The Use of Drugs in Food Animals: Benefits and Risks. Washington, D.C.: The National Academies Press, 1999.
2.
www.waters.com/waters/en_US/Solvents-and-Caveats-for-LC-MS/ nav.htm?cid=10091173&locale=en_US
The authors are with SIELC Technologies, 804 Seton Ct., Wheeling, Ill. 60090, U.S.A.; tel.: 847-229-2629; e-mail:
vlad.orlovsky@sielc.com;
www.sielc.com. The authors would like to acknowledge all scientists and engineers at SIELC.
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