Lyme Disease and Food Allergies Most Lyme patients end up seeing me because they are experiencing allergy and sensitivity symptoms. There is a great deal of crossover between mast cell activation disorders (in which I specialize) and Lyme. This is because B. burgdorferi can directly cause mast cell degranulation. Mast cells are the cell within our immune system that carries histamine and other mediators including tryptase and heparin. Their job is to respond to allergens and inflammation. Typically, when the IgE receptor is stimulat- ed by an antigen (typically a substance one is allergic to), the mast cell degranulates losing its histamine load. This can cause a variety of symptoms including congestion, runny nose, itchy/watery eyes, itchy skin, hives, asthma, coughing, wheezing, tachy- cardia, flushing, angioedema, changes in blood pressure, frequent/urgent urination, constipation, diarrhea, acid reflux, nausea, vomiting and even anaphylactic shock. I have seen onset of allergic symptoms in Lyme occur typically following an aggres- sive treatment such as IV antibiotics. This may start with hives following the antibiotic and may progress to symptoms even when not undergoing actual treatment. For many patients, this may result in loss of tolerance (allergy) to one or more types of antibiotics.
Lyme Disease and Mast Cell Activation For a particularly unlucky subset of
Lyme patients they may develop mast cell activation syndrome (MCAS). This is a dis- order where the immune system over reacts to various stimuli causing them to appear to be allergic to many things in the world around them. There is no real increase in
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