Cognitive Decline In 2012, scientists reported that vitamin D deficiency is linked


to cognitive impairment (Scand J Clin Lab Invest Suppl. 2012). They explained that vitamin D receptors are widespread in brain tissue, and that the biologically active form of vitamin D has shown neuro- protective effects, including the ability to clear amyloid plaques, a hallmark of Alzheimer’s. They also reported that two large prospec- tive studies indicate that low vitamin D may increase the risk of cognitive decline, but encouraged the development of large, ran- domized controlled trials to determine whether vitamin D supple- mentation can prevent or treat Alzheimer’s disease and dementia.


COPD (Chronic Obstructive Pulmonary Disease) Pulmonary rehabilitation is an important treatment for COPD


patients, who are often vitamin D deficient. Exactly how vitamin D affects COPD development is unclear. However, its deficiency increases with the severity of the disease, and studies show that vitamin D can alter immune cell activity, inhibit inflammatory response, and regulate airway smooth muscles. One study of 151 subjects found that higher plasma levels of vitamin D are associated with increased exercise capacity in COPD patients (Ann Med. 2013 Feb). In another study of 50 COPD patients, researchers discovered that monthly doses of 100,000iu significantly improved respiratory muscle strength and oxygen uptake (Respiratory Research 2012 September).


Depression/SAD


It is well-established that vitamin D deficiency can cause seasonal affective disorder (SAD) and general depression. In one four-year study of 12,594 patients, researchers concluded that low vitamin D levels are associated with depressive symptoms and that patients with a history of depression may be an important target for assessment of vitamin D levels (Mayo Clin Proc. 2011 Nov).


According to Dr. Holick, animal studies have shown that vita- min D will elevate mood by increasing serotonin levels in the brain. It is thus thought that healthy vitamin D status can improve people’s serotonin levels, mood, and general feeling of well-being.


Osteoarthritis (OA) OA is the most common joint disorder in the United States. Old age, female gender, overweight/ obesity, knee injury, repetitive use of joints, bone density, muscle weakness, and joint laxity, all play roles in the development of OA, particularly in the weight- bearing joints.


Low tissue levels of vitamin D may impair bone’s ability to re- spond optimally to processes in OA and thus predispose to disease progression. One study reported that low intake and low serum levels of vitamin D each appear to be associated with a three-fold increased risk for progression of OA of the knee (Ann Intern Med. 1996 September).


Another study found that high levels of vitamin


D protected against hip OA characterized by joint space narrowing (Arthritis Rheum. 1999 May). In this writer’s experience, the proper doses of vitamin D with calcium, magnesium, and other micronutri- ents, reverse osteoarthritis.


Given the ample historical support in the scientific literature for vitamin D3 supplementation in connection with a wide variety of conditions, it would best serve patients to take into account its importance to lifelong health maintenance.


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The statements in this article have not been evaluated by the


Food and Drug Administration. Unless otherwise stated herein or otherwise supported by specific research, the natural remedies discussed herein are not intended to diagnose, treat, cure or prevent any disease.


Submitted by Michael Dworkin, PD, CCN, a Registered Pharmacist and State Certified Clinical Nutritionist (CT Certification No. 232), with J. Erika Dworkin, Certified Lifestyle Educator and Board Cert. Holistic Nutrition (pending). Owner of the Manchester Parkade Health Shoppe (860.646.8178, 378 Middle Turnpike West, Manchester, CT, www.cthealthshop.com), Pharmacist Dworkin has been guiding patients since 1956 and is available for consultation by appointment. Erika is available to speak to groups. All statements in this article are research-based and references are available upon request. See ad on page 11.


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