RAMAN SUPPLEMENT
DETECTION, DETERMINATION OF CHEMICAL COMPOSITION
Klara Dégardin
F. Hoffmann-La Roche & Institute of Forensic Science, University of Lausanne Yves Roggo
F. Hoffmann-La Roche Pierre Margot & Frederic Been Institute of Forensic Science, University of Lausanne
Raman spectroscopy has become a widespread technique for the analysis of pharmaceutical solid forms. The application proposed here is the investigation of counterfeit medicines. This serious global issue requires quick and accurate identification methods to fight against this phenomenon. Thanks to its chemical selectivity, rapidity of analysis and potential of generating repeatable spectral profiles, Raman spectroscopy presents distinct advantages for the analysis of counterfeits. Combined with chemometric tools, the technique enables the detection, the determination of chemical composition and the profiling of medicine counterfeits.
Medicine counterfeiting is a crime and has become a topical public issue over recent years due to its industrial development. Every week,
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European Pharmaceutical Review Volume 16 | Issue 5 | 2011
new instances are discovered around the world1 and according to the World Health Organisation (WHO), 10 per cent of the world’s medicines are
counterfeits. The proportion has been increasing, thanks to the boom in Internet commerce2
. Several kinds of counterfeit
medicines currently plague society, including some devoid of any Active Principal Ingredient (API) and others containing toxic compounds. The main targets are life-saving medicines in developing areas while lifestyle medicines and more recently cancer medicines constitute the best opportunities for counterfeiters3
in
industrialised countries. The main reasons behind medicine counterfeiting are the absence of deterrent legislation, lax enforcement of what
AND CHEMICAL PROFILING OF COUNTERFEIT MEDICINES BY RAMAN SPECTROSCOPY
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