RAMAN SUPPLEMENT Mike Kayat


Vice President, B&W Tek Inc


Pavel Matousek


Chief Scientific Officer, Cobalt


ROUNDTABLE LEADERS Mike Claybourn


Raman Product Manager, HORIBA Scientific


Ian Lewis Marketing Manager, Kaiser Optical Systems Inc Ken Williams


International Sales Manager and Applications Specialist, Spectroscopy Products Division, Renishaw plc


Moderator: Don Clark Pfizer Global R&D


Excluding safety and sample preparation advantages, what does Raman spectroscopy offer over other spectroscopic techniques in the analysis of pharmaceutical samples?


Mike Kayat: Raman spectroscopy offers a broad spectral range, from less than 100 cm-1 4000 cm-1


to over , which covers a wide variety of


important functional groups, allowing it to measure organic and inorganic samples. Sharp spectral peaks enable both qualitative and quantitative chemometric analysis. Raman is insensitive to aqueous absorption bands. Coupled with enhancement techniques like SERS, Raman can provide parts per billion trace identification. Finally, Raman instruments can be deployed from the lab to the loading dock and to the process line for analysis of pharmaceutical materials.


Mike Claybourn: The main competing spectroscopic techniques in my view are near infrared and ssNMR. The major advantages over these techniques include its flexibility in


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sampling from whole formulations through to fast mapping of tablets at micron spatial resolution. The scale of scrutiny is significant in targeting quality attributes through the drug development process and manufacturing. It is more sensitive than NIR through better spectral discrimination and does not have the strong scattering background in NIR. It is more sensitive than ssNMR for say low levels of polymorph. Measurements can be done in seconds compared to hours.


Ken Williams:When combined with a research grade optical microscope, it offers the benefits of sub-micrometre and variable resolution to enable the generation of chemical images. Raman can easily identify polymorphic forms of actives within solid formulations, combined with imaging and particle sizing, providing a powerful method for qualitative and semi- quantitative analysis.


Pavel Matousek: It offers high chemical specificity combined with high spatial resolution, which is particularly beneficial in


imaging applications. In addition, the technique’s ability to perform deep non-invasive analysis and its compatibility with water, allows intact detailed bulk analysis of many types of pharmaceutical formulations in quality and process control applications.


Ian Lewis: Spectral interpretation can lead to information and understanding on chemical structure, as well as chemical and physical properties. Raman, being a non-destructive analysis technique, can start to be used in discovery in the screening stage, as an analysis approach Raman can follow the chemical species into reaction scale-up, crystallisation, etc and into API manufacturing. In formulation, Raman can be used as an in-coming good inspection (raw materials ID) approach, in formulations development, in-situ unit operation control tool, and for final product verification. While one instrument isn’t capable of doing all of these, the basic analysis approach of Raman, band position of interest, and in some cases spectral conditions including excitation wavelength, resolution, spectral coverage can


European Pharmaceutical Review 19 Volume 16 | Issue 5 | 2011


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