RAMAN SUPPLEMENT


conformations, and dynamical disorder corresponding to rotations of small groups of atoms. These investigations and the monotropic character of phase II, only obtained upon heating from a deeply quenched liquid (Tg


– 40


“Molecular organic compounds go through several stages of


processing (milling, freeze-drying, spray-drying, pressurising) for packaging as solid-dosage form”


K) suggest that phase II could be considered as a very metastable state in the devitrification process toward the stable phase I, in agreement with Ostwald’s rule of stages32


.


FIGURE 10 Low-frequency Raman spectra of under-cooled liquid, phases I and II of Ibuprofen at -80°C a) Reduced intensity; the grid area of the spectrum corresponds to the QES of phase II b) Raman susceptibility The arrows localise features of phase II considered as Raman signatures of the long-range order in phase I, and stars indicate laser lines


dynamical disorder of atom groups in phase II at low-temperature. Consequently, phase II can be described from the long-range order similar to


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that of phase I, with the consideration of static disorder inherent to a disordered distribution of enantiomers characterised by slightly distorted


This paper shows that Raman spectroscopy


is suitable for predicting the process induced transformation during manufacturing, via the analysis of the influence of temperature, pressure and so forth on APIs. Micro-structural information in solid dosage forms can also be obtained by micro-Raman spectroscopy.


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