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5. Januszewski, A.S.; Alderson, N.L. et al. Role of lipids in chemical modification of pro- teins and development of complications in diabetes. Biochem. Soc. Trans. 2003, 31, 1413–16.


6. Rodríguez-García, J.; Requena, J.R. et al. Increased concentrations of serum pento- sidine in rheumatoid arthritis. Clin. Chem. 1998, 44(2), 250–5.


7. Thorpe, S.R. and Baynes, J.W. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs & Aging 1996, 9, 69–77.


8. Yan, S.D.; Wautier, J.L. et al. Cellular recep- tors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogen- sis of vascular lesions. Arterioscler Thromb. 1994, 14, 1521–8.


9. Vlassara, H. Recent progress on the biologic and clinical significance of advanced gly- cosylation end products. J. Lab. Clin. Med. 1994, 124, 19–30.


10. Bucala, R. and Cerami, A. Advanced glyco- sylation: chemistry, biology, and implica- tions for diabetes and aging. Adv. Pharma- col. 1992, 23, 1–34.


11. Onorato, J.M.; Jenkins, A.J. et al. Pyridox- amine, an inhibitor of advanced glycation reactions, also inhibits advanced lipoxidation reactions. Mechanism of action of pyridox- amine. J. Biol. Chem. 2000, 275, 21,177–84.


12. Anderson, N.L.; Chachich, M.E. et al. The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats. Kidney Int. 2003, 63, 2123–33.


13. Requena, J.R. and Baynes, J.W. Studies in Animal Models on the Role of Glycation and Advanced Glycation End Products (AGEs) in the Pathogenisis of Diabetic Complications: Pitfalls and Limitations. Sima, A.F., ed. Har- wood Academic Publishers: Amsterdam, 2000, pp 43–69.


14. http://www.americanlaboratory. com/913-Technical-Articles/18626-Modi- fications-of-DNA-in-Relation-to-Diabetes- Identification-of-Carboxymethyl-2-Deoxy- adenosine-From-Glycoxidation-Reactions- Calf-Thymus-DNA-Human-Urine-and-DNA/.


AMERICAN LABORATORY • 39 • AUGUST 2015


15. http://www.americanlaboratory. com/913-Technical-Articles/122551-Mod- ification-of-DNA-in-Relation-to-Diabetes- Identification-of-CMdC-From-Glycoxida- tion-Reactions-and-Estimation-of-CMdC- and-CMdA-in-Fasting-Human-Urine/.


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17. Lila, Z.A.; Thomas, Y. et al. DNA modifi cation in diabetics and obese persons: detection of carboxymethyl-2’-deoxycytidine (CMdC) in biological sample. Proceedings of the Network of Minority Research Investigators, April 15–17, 2015, Bethesda, Md.


18. Lila, Z.A.; Flowers, D. et al. Modification of DNA (dA) and RNA (A) in relation to diabetes and obesity: detection of carboxymethyl- 2’-deoxyadenosine (CMdA) and carboxy- methyl-adenosine (CMAd) in diabetic and obese urine. Proceedings of the Network of Minority Research Investigators, April 14–15, 2014, Bethesda, Md.


Zeenat Ara Lila and Louis D. Whitesides are with the 1890 Research Department, South Carolina State University, 300 College St., Orangeburg, S.C. 29117, U.S.A.; tel.: 803-533-3925; fax: 803- 533-3792, e-mail: zlila@scsu.edu. Chukudi Weze and Yazmine Thomas are with the Department of Biological and Physical Sciences, South Car- olina State University. The authors acknowl- edge the following: 1890 Evans-Allen Research Program, South Carolina State University; Dr. William E. Cotham, associate director, Mass Spectrometry Laboratory, University of South Carolina; Dr. Brian W. Kendall, medical director, Hospitalist Services, Regional Medical Center, Orangeburg, S.C.; Mr. Gary C. Ferguson, direc- tor, Department of Pathology and Laboratory Medicine, Regional Medical Center; Mr. Erik J. Simensen, program director, Institute of Pub- lic Health Research and Outreach, Orangeburg, S.C.; Mrs. Pamela Laursen, grants coordinator, 1890 Research; and Mrs. Shobha Choudhari, statistician, 1890 Research.


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