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Researcher


Institution


Dr. Kris Chadee University of Calgary


Project


The large intestine is covered with thick mucus that forms a protective barrier against bad bacteria and


substances. However, in IBD the mucus layer is very thin and the inflamed gut becomes susceptible to bacterial invasion and other noxious substances that exacerbate inflammation. Dr. Chadee is studying the role of Muc2 mucin in maintaining a healthy microbiome and protective barrier as a treatment option for IBD.


Keywords: mucin in host defense; epithelial barrier function; tight junction proteins; permeability; gut leakiness.


Dr. Kevan Jacobson


BC Children’s Hospital


The cells lining the gut form a physical barrier between the contents of the digestive tract and


the underlying immune and nervous systems. This is achieved by tight junction proteins that bind neighbouring cells together. In IBD this physical barrier is impaired. Dr. Jacobson is investigating ways to prevent disruption, and strengthen the barrier to develop new therapies for IBD.


Keywords: tight junction proteins; barrier function; nervous system


$119,436 (Year 3 of 3)


Investment $119,445 (Year 3 of 3)


RESEARCH REPORT 2014 | 20


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