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PEER-REVIEW | FACIAL AESTHETICS | treating physician before and after treatment using the


Wrinkle Assessment Scale (WAS), and patients rated their appearance at each post-treatment visit using the Global Aesthetic Improvement Scale (GAIS). Patients were evaluated at 1, 2, 6, and 12 weeks post-treatment. All patients were treated to maximal (no over-)


correction, with a mean reduction in WAS score of 2.12 +/- 0.56. No patient noted any fibrosis, irregularity, hardness, restricted movement, or lumpiness. The author of the study concluded that PRFM can provide significant long-term diminution of deep nasolabial folds without the use of foreign materials. PRFM holds significant potential for stimulated dermal augmentation. (NB. The system used in this study uses thrombine to get a stronger fibrin mesh and therefore cannot be defined as 100% autologous.)


Objective results A study by Amgar et al41


is one of the very few


expressed as a percentage. Following marked swelling of the skin, a number of micro-lines on the surface of the skin can be observed. The projection and distribution of


these micro-lines,


two-dimensionally in all directions (360°), is indicative of young skin. The older the skin, the more these lines will change orientation and become parallel. The study tracked 37 patients for a period of 3 weeks following PRP treatment, and 27 for an additional 10 weeks post-treatment. A good anti-ageing


With the accumulated knowledge on this procedure,


studies concentrating only on the objective results of PRP. It uses biometric parameters for scientifically measurable means of assessing the results from the PRP injections. Skin hydration was made after compensating for the ambient humidity level. The hydration was expressed by a standard index. Anisotropy measures the distribution of micro-lines in 360°, and is


References


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40 ❚


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18. Martínez-Zapata MJ, Martí-Carvajal A, Solà I et al. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 2009; 49(1): 44–56


19. Fitzpatrick RE, Rostan EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther 2003; 5(1): 25–34


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22. Schmitz JP, Hollinger JO: The biology of platelet-rich plasma. J Oral Maxillofac Surg 2001; 59(9): 1119–21


23. Marx RE The biology of platelet-rich plasma. J Oral Maxillofac Surg 2001; 59(9): 1120


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25. Liu Y, Kalén A, Risto O, Wahlström O. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Repair Regen 2002; 10(5): 336–40


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27. Fennis JP, Stoelinga PJ, Jansen JA. Mandibular reconstruction: a clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma. Int J Oral Maxillofac Surg 2002; 31(3): 281–6


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31. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007; 9(3): 174–83


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37. Cho JM, Lee YH, Baek RM, Lee SW. Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plas Reconstr Aesthet Surg 2011; 64(2): e31–9


38. Almeida Issa MC, Piñeiro-Maceira J, Farias RE, Pureza M, Raggio Luiz R, Manela-Azulay M. Immunohistochemical expression of matrix metalloproteinases in photodamaged skin by photodynamic therapy. Br J Dermatol 2009; 161(3): 647–53


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41. Amgar G, Bonnet C, Butnaru A, Herault-Bardin F. Using objective criteria to evaluate cosmetic effects of platelet rich plasma. PRIME 2011; 1(6): 30–41


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43. Na JI, Choi JW, Choi HR et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg 2011; 37(4): 463–8


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we now have the most complete, versatile and active treatment for skin rejuvenation and anti-ageing.


effect was assessed by measured anisotropy values of -24.1% and -16.9%., respectively. Additionally, a cross-analysis involving the initial anisotropy readings demonstrated further improvement. The anisotropy correlates were -33% and -39.7%, respectively, if the treatment is provided to patients who would mostly benefit from it (anisotropy > 30%). The study also demonstrated that the effects of one PRP treatment could last for up to 10 months.


In another study which combined PRP with fractional laser therapy for dermal rejuvenation42


, a


high concentration of PRP induced an up-regulation of type I collagen, MMP-1, and MMP-2 expression in human skin fibroblasts. Taken together, PRP treatment induced an increase in expression of G1 cell cycle


June 2013 | prime-journal.com


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