36 PROCESSING TECHNOLOGY
Streamlined, flexible operations demanded for control strategies
As two major new bio-investments show, the need for streamlined, flexible manufacturing is driving investment in the latest control technologies. Sean Ottewell explains.
Comme le montrent deux nouveaux investissements majeurs dans le domaine des biotechnologies, le besoin d’une fabrication rationalisée et souple oriente l’investissement vers les technologies de contrôle les plus récentes. Les explications de Sean Ottewell.
Wie zwei umfangreiche neue Investitionen in die Biotechnologie belegen, werden Investitionen in neueste Kontrollverfahren von der Forderung nach einer optimierten und flexiblen Herstellung motiviert. Ein Bericht von Sean Ottewell.
G
enetic disease specialist Shire Human Genetic Therapies (HGT) is investing US$250m in a new production facility at Lexington,
Massachusetts, USA. The facility is scheduled for completion in spring 2010 and when complete will be the largest disposable biotechnology site in the country. This is a new concept where disposable
vessels and tank liners are used to reduce the cost of cleaning and verification of process equipment. The site also will include cell-culture production, a clinical suite, and just-in-time warehousing. “Technology that simplifies scale-up from
R&D to commercialised production is critical for biotech facilities to produce as efficiently and reliably as possible,” explained Don Wuchterl, director of manufacturing with Shire HGT. In order to control
manufacturing processes at the new facility, Shire HGT has selected a number of Honeywell solutions, including Experion Process Knowledge System (PKS), Experion Batch Manager, the OneWireless industrial wireless network and Uniformance Process Historian Database (PHD).
“Experion and OneWireless are
proven to streamline operations and will provide the flexibility required for a multi-purpose facility such as ours,” added Wuchterl. Shire will use Experion as the primary control platform for the new facility. The system helps operators run production by integrating critical subsystems throughout the plant, providing a single view into the manufacturing process via Experion client operator stations. The processing capacity of the C300 controller will reduce the amount of hardware needed to automate Shire’s manufacturing process, as well as reduce operating costs. Shire will also use one of the newest additions to the Experion
product line, Experion Batch Manager. Introduced in 2008, Experion Batch Manager further simplifies operations by allowing manufacturers to quickly execute complex batch recipes reliably in a regulated environment. Additionally, the OneWireless mesh network technology will allow Shire to mount controllers on moveable equipment without having to worry about cabling issues, which can help increase their production flexibility, safety and efficiency. Also, wireless remote operator stations will be used to help reduce the overall number of stations required and eliminate the need for expensive hardened enclosures in environmentally sensitive areas. For its part, PHD will pull information from
Fig. 1. Operations management software will be used to boost cell culture capabilities at the new facility.
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