34 chromatography/spEctroscopy
➠
available. With a mass of only 28kg, it is configured with profiles. A key advantage is that fingerprinting is a fully
a 12-position sample changer, a helium gas attachment automated method without the need for interpretation.
for light element analysis and a Mo anode X-ray tube. The benefits of XRF include: fast and accurate
In most cases pharmaceutical materials are measured elemental analysis; sample preparation made easy; direct
in their natural form. Powder materials are simply placed analysis of liquids/powders/solids; no chemical reagents,
into a cup with a plastic foil and then loaded into the less waste; unattended automated analysis; suitable
spectrometer. for non-experts; unmatched repeatability with minimal
Most liquids can be analysed without special recalibration; unknown contaminant identification.
treatment simply using a plastic cup, which has a The advantages of MiniPal 4 Pharma include:
protective plastic foil that functions as a base. All that is configuration to support pharmaceutical industry
required is to fill the sample cup with a freshly prepared, regulations; non-destructive, multi-element analysis; best
well mixed sample. resolution in class; robust, reliable and cost effective.
PANalytical has fully equipped application laboratories
Screening and quantification
in Japan, China, the USA and the Netherlands.
In recent years it has become common practice to PANalytical's research activities are based in Almelo
screen all incoming production materials within the (NL) and on the campus of the University of Sussex in
pharmaceutical community. The fingerprinting technique Brighton, UK.
is applicable to all materials including liquids, powders Competence and supply centres are located on
and solids. two sites in the Netherlands: Almelo (development
The proven and powerful MiniPal software is and production of X-ray instruments) and Eindhoven
sophisticated yet easy to use, allowing users to quickly (development and production of X-ray tubes). u
identify and classify incoming raw materials.
The MiniPal FingerPrint software employs a Enter 34 or ✔ at www.scientistlive.com/elab
sophisticated statistical algorithm that examines the
entire scan. This includes features which are not normally Ian Campbell is product manager XRF, PANalytical, Almelo,
interpreted by XRF, such as peak shape and background The Netherlands. www.PANalytical.com
Fig. 2. Calibration line representative of Platinum group Fig. 3. Calibration line representative of heavy metal
catalyst used for the production of API. contamination potentially from various sources.
Fig. 4. Stainless steel materials used in the production such as
grinding and tableting
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