34 CHROMATOGRAPHY/SPECTROSCOPY
➠
available. With a mass of only 28kg, it is configured with a 12-position sample changer, a helium gas attachment for light element analysis and a Mo anode X-ray tube. In most cases pharmaceutical materials are measured in their natural form. Powder materials are simply placed into a cup with a plastic foil and then loaded into the spectrometer.
Most liquids can be analysed without special
treatment simply using a plastic cup, which has a protective plastic foil that functions as a base. All that is required is to fill the sample cup with a freshly prepared, well mixed sample.
Screening and quantification
In recent years it has become common practice to screen all incoming production materials within the pharmaceutical community. The fingerprinting technique is applicable to all materials including liquids, powders and solids. The proven and powerful MiniPal software is sophisticated yet easy to use, allowing users to quickly identify and classify incoming raw materials. The MiniPal FingerPrint software employs a sophisticated statistical algorithm that examines the entire scan. This includes features which are not normally interpreted by XRF, such as peak shape and background
profiles. A key advantage is that fingerprinting is a fully automated method without the need for interpretation. The benefits of XRF include: fast and accurate
elemental analysis; sample preparation made easy; direct analysis of liquids/powders/solids; no chemical reagents, less waste; unattended automated analysis; suitable for non-experts; unmatched repeatability with minimal recalibration; unknown contaminant identification. The advantages of MiniPal 4 Pharma include:
configuration to support pharmaceutical industry regulations; non-destructive, multi-element analysis; best resolution in class; robust, reliable and cost effective. PANalytical has fully equipped application laboratories in Japan, China, the USA and the Netherlands. PANalytical's research activities are based in Almelo (NL) and on the campus of the University of Sussex in Brighton, UK.
Competence and supply centres are located on
two sites in the Netherlands: Almelo (development and production of X-ray instruments) and Eindhoven (development and production of X-ray tubes). u
Enter 34 or ✔ at
www.scientistlive.com/elab
Ian Campbell is product manager XRF, PANalytical, Almelo, The Netherlands.
www.PANalytical.com
Fig. 2. Calibration line representative of Platinum group catalyst used for the production of API.
Fig. 3. Calibration line representative of heavy metal contamination potentially from various sources.
Fig. 4. Stainless steel materials used in the production such as grinding and tableting
www.scientistlive.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44