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MEDICAL


to gather information. Te advantage is that the chemicals traditionally used to label biopsy samples in a lab could be harmful if used directly inside the human body. ‘We couldn’t simply shrink a microscope that


has dozens of distinct bulky parts,’ explained Li, ‘so we started a new design from scratch.’ A short-pulsed laser was used to create bursts of photons and transmit them down a specially designed, flexible fibre optic cable connected to the probe. Tey then travelled through a miniature lens, which also functions to refocus the light emitted by the cells and send it back to detectors through the same cable. Te team designed the probe to capture 3D


images by incorporating a very small scanner. Te lens was carefully fashioned to focus the long-wavelength light emitted from the laser, while also collecting the short-wavelength fluorescence light emitted from the cells; the fibre optic cord, too, was bespoke to transmit both the excitation and fluorescence light, while minimising the background noise generated in the fibre optic cable. Te second probe developed by the team was


an ultra-thin OCT probe, which the researchers said allowed them to gain three to four times higher resolution when compared to similar technologies in clinical use today. ‘To achieve this,’ said Li, ‘we had to use a light source with


The CapsoCam Plus capsule endoscope has four cameras to give 360° panoramic lateral imaging


a broader spectrum of colour, and the challenge was to focus all those colours onto a single spot without making the image look fuzzy. Cameras do this by using a large lens, but we did not have that luxury.’ Te probe’s size was reduced by about half that of those currently in use, to about 500µm in diameter. Li and his team simplified the design by


forming the end of the fibre optic cord into a tiny ball lens made out of silica, which was able to work as well as its larger counterpart. Te ball lens is then ground and coated with gold to reflect and focus the light onto the tissue. Te small probe had the additional benefit of improved flexibility, allowing the researchers to access and image small lumens in complex organs in animals with much clearer visualisation on tissue structures. Te ultimate aim is for this


developments in this field since the creation of the then-milestone quarter-inch CCD image sensor chip-on-tip solution, to fit inside the 6.5mm inner diameter of an endoscope in the 2000s. For this application, ultra-compact camera


We couldn’t simply shrink the microscope, which has dozens of distinct bulky parts


kind of technology to be more readily available and at a realistic price point, as Li explained. ‘Ultimately,’ he said, ‘we want to be able to get images good enough so that we don’t have to remove tissue from the patient.’ Te research team are hopeful that they will soon be able to begin clinical trials for their OCT and two-photon probes to establish their viability for use in humans in terms of safety and effectiveness. Te probe, estimates Li, costs less than $1,000 to produce, and he believes that this cost could see a dramatic reduction if it goes into mass production.


NET modular camera concept for long distance remote-head applications


Single use Camera maker New Electronic Technology (NET) believes single-use endoscopy is the way forward for surgeons and patients, and so has been applying its knowledge to make


18 Imaging and Machine Vision Europe • August/September 2018


technology is demanded to minimise health risks and speed-up convalescence, and the company developed a CMOS camera assembly measuring 1.6mm in diameter with integrated fibre optic lighting. Single-use in this way has the benefit of minimising the infection risks caused by cross- contamination and, Grzegorz Kolodynski, marketing and PR at NET, said ‘the technology could also be applied for the inspection of working channels in multi-use endoscopes’. Te image sensor features a


native resolution of 400 x 400 pixels at 30 frames per second


for live videos, and the camera solution features a modular design and remote image sensor head, with up to three-metre cabling, and additional five metres from camera electronics to camera control unit. Simultaneous image output via HDMI and USB3 allows image transfer to tablets and PCs, or monitors for real- time display. Kolodynski added: ‘Latency-free image improvement for real-time image display via HDMI video-out supports the work of surgeons, and a colour stretch function enables an improved perception of red-ish colour tones, which is especially useful for surgical applications.’ Te camera concept means sensor electronics


can be relocated from the tip to the handpiece of medical devices to serve various demands better, he added. O


@imveurope www.imveurope.com


NET


CapsoVision


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