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Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Digital & Circulation Manager Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


Airfreight and mailing in the USA by agent named Air Business Ltd, c/o Worldnet Shipping Inc, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERY WORLD DDW, Air Business Ltd, c/o Worldnet Shipping Inc, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA Subscription records are maintained at RJ Communications & Media Ltd, 39 Vineyard Path, London, SW14 8EL, United Kingdom Air Business Ltd is acting as our mailing agent.


© 2018 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


d r u g d i s c o v e r y wo r l d contents VOLUME 19 ISSUE 3 ● SUMMER 2018


Introduction Dr Roger Brimblecombe Consultant Editor


Precision Medicine Precision Medicine Drugs – Pleonasm or Reality? Dr Urban Kiernan and Dr Stephen Naylor


Business Improving Productivity With Better Predictivity Dr Lorna Ewart, Dr Richard Goodwin, Dr Stephen Fawell, Dr Pernille Laerkegaard Hansen, Dr Catherine Priestley, Steve Rees and Dr Menelas Pangalos


Therapeutics Antibiotics and AMR – A Global Perspective Professor Anthony Coates and Dr Yanmin Hu


Drug Discovery The Mass Spectrometry Innovations Simplifying Drug Discovery Workflows Helen Stewart-Miller and Dr Richard Massey


Business Disruptive Approaches to Accelerate Drug Discovery and Development Part II: Emergent Intelligence, a New Paradigm for Drug Discovery Dr Anton Fliri, Dr Palaniyandi Manavaskam, Dr Shama Kajiji, Dr Gerald Lushington and Dr Rathnam Chagaturu


Therapeutics Advances in Analytical Biophysical Tools to Accelerate the Discovery of Therapeutic Antibodies Dr Yasmina Noubia Abdiche


Microfluidics Microfluidics – Driving Innovation and Streamlining Single Cell Analysis Dr Frank Craig


Informatics Data-Driven Transformation in Drug Discovery Dr Satnam Surae


Therapeutics Preserving Cell Integrity and Viability to Drive the Discovery of Cell Therapies Mary Kay Bates


7 9


18


26 34 42 55 61


68 74


Front cover illustration courtesy of Phil Jude/Science Photo Library Drug Discovery World Summer 2018 5


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