Sample Management


Figure 10: Aspects of the sample deposition and storage process respondents felt most critical to their group’s success


Strict adherence to protocol


Maintaining audit trail and ID tracking


Process large numbers quickly Maximising sample available Minimising processing time


3.31 3.26 2.68 2.63


1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 MEAN RANKED ORDER 1 to 5, where 1 = least critical and 5 = most critical


© HTStec 2016 3.68


Figure 11: Valued placed on a continuous audit trail of sample ID and temperature excursions


Moderate value – to flag samples exposed to temperature variation


Major value – all samples that exceeded certain temperature criteria could be automatically flagged and removed from the active inventory


Minimal value – would not impact subsequent sample use or processing


No value 2%


0% 5% 10% 15% 20% 25% 30% 35% 40% 45% 50% 55% % Responding


© HTStec 2016 17% 31% 50%


Figure 12: Most valuable features wanted in any new sample ID and quality tracking technology


Operates in the temperature ranges required for all of your storage needs


Reliable sample identification with a read rate approaching 100%


Sample ID can be read through frost and ice or in areas of high humidity


Provides a complete lifecycle audit trail of sample ID and temperature changes


Visual alert indicator for ‘over temperature’ events at the individual sample level


allowing cost-effective user implementation Proven to integrate well with LIMS


systems already on the market


Includes a redundant back up ID system Has a proven API integration framework


Integrates to robotic handling to eliminate the risk of human handling errors


Capture temperature and a ‘lot ID’ of the rack or cryo box at a macro level versus at the individual sample level


No LIMS required and will maintain a proper record for your chain of custody audits and inventory management needs


3.50


3.35 3.39 3.43 3.44


1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 MEAN RATING SCALE 1 to 5, where 1 = no value and 5 = high value


© HTStec 2016 3.80 3.61


Bluechiip (www.bluechiip.com) provides wireless ID tracking and temperature sensing technology that survives and operates in extremely harsh envi- ronments such as cryogenic temperatures and ion- ising radiation. The offering comprises hardware, software and engineering support targeting both end-users and OEM partnerships. Bluechiip core technology hardware consists of the actual MEMS- based chip and the interrogator. The chip can have different packaging configurations to suit a wide range of applications and encapsulation processes. As an example, the Bluechiip tag can be co-injected in vials, mechanically attached with glue or just loosely enclosed in a cavity. The antennas can also


34 Drug Discovery World Summer 2017 4.09 4.02


4.40 4.41


Improving stored sample quality Survey respondents ranked strict adherence to pro- tocol as the aspect of the sample deposition and sample storage process they felt most critical to their group’s success. This was followed by main- taining audit trail and ID tracking; and then min- imising processing time. Ranked the least critical was process large numbers quickly (Figure 10). Most (50%) of survey respondents placed mod- erate value (ie to flag samples exposed to tempera- ture variation) on a continuous audit trail of sample ID and the temperature excursions a sample has been exposed to during its lifecycle. This was fol- lowed by major value (ie all samples that exceeded certain temperature criteria could be automatically flagged and removed from the active inventory) (31% using); minimal value (ie would not impact subsequent sample use or processing) (17% using); and then no value (2% using) (Figure 11). The most valuable features wanted in any new sample ID & quality tracking technology is pre- sented in Figure 12. This showed that survey respondents rated operates in the temperature ranges required for all of your storage needs as the most valuable feature wanted in any new technol- ogy. This was closely followed by reliable sample identification with a read rate approaching 100%; and then sample ID can be read through frost and ice or in areas of high humidity; and provides a complete lifecycle audit trail of sample ID and tem- perature changes. Rated least value was no LIMS required and will maintain a proper record for your chain of custody audits and inventory man- agement needs.


Latest vendor developments The following vendor snapshots describe some of the latest developments in sample identification tracking and technologies for maintaining the qual- ity of stored samples.


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