Monitoring & metering
manufacture where it ensures safety and efficacy. It can be used in the development of virus-based vaccines, for diseases such as influenza, swine flu, and potentially COVID-19. Refractometers determine the
concentration of dissolved solids by making an optical measurement of a solution’s refractive index (RI) and temperature. The monitoring of RI can improve the understanding of process conditions, reduce drug development time, increase production capacity and stability, improve product quality, and demonstrate compliance with regulations. Pharmaceutical manufacturers are required to demonstrate process validation from drug discovery to full production, and this can be achieved through RI measurements. The Vaisala refractometers were specially
designed for the pharmaceutical industry where the refractometer measures dissolved components in liquids. This includes the continuous measurement of sucrose densities in the virus purification process. After centrifugation, the viruses band to a specific sucrose density gradient, and by measuring that density with the refractometer the viruses can be safely and efficiently collected. With these reliable measurements, vaccines can be developed as quickly and as safely as possible without compromising on quality.
Technology for ensuring effecTive bio-deconTaminaTion
Innovative Vaisala measurement technology is deployed in frontline bio-decontamination work to kill harmful organisms such as viruses on surfaces. For example, Cleamix Oy performed hydrogen peroxide vapour bio- decontamination work in South Korea during the coronavirus outbreak in early 2020. The Cleamix portable hydrogen peroxide vapour generators use Vaisala’s HPP270 series probes to monitor and control vapour output during bio-decontamination. Hydrogen peroxide vapour is capable of
killing even the most resistant microorganisms, which is why it is utilised in the disinfection of critical spaces. Decontamination requires specific concentrations for specific periods of time. Furthermore, hydrogen peroxide is an unstable gas so it has to be monitored closely. It is also a costly resource so its use needs to be optimised.
In the absence of hydrogen peroxide vapour, the relative humidity of air is equal to the relative saturation. When vapourised hydrogen peroxide is introduced, the relative saturation becomes greater than the relative humidity. Relative saturation is a parameter that indicates the humidity of the air caused by both hydrogen peroxide vapour and water vapour. When relative saturation reaches 100%RS, the vapour mixture starts to condense. Monitoring the relative saturation value during a process is therefore crucial, because it indicates the saturation point of the combined vapours. The unique Vaisala PEROXCAP hydrogen
Instrumentation Monthly August 2020 31
peroxide sensor employed by the HPP272 probe measures relative saturation as well as dew point and vapour pressure, which can also be critical parameters in decontamination. The probe therefore guarantees stable, reliable and precise hydrogen peroxide measurements throughout the decontamination cycle, even in high humidity. It is therefore utilised by the manufacturers of bio-decontamination equipment around the world.
moniToring pharmaceuTical and healTh care faciliTies
Vaisala’s industrial instruments and systems are routinely employed to monitor critical conditions in a wide variety of pharmaceutical and healthcare applications. Monitoring is essential in these circumstances because most pharmaceutical production processes, including transport and storage, have to be undertaken in strictly controlled environmental conditions. Vaisala’s technologies are therefore utilised in research, manufacturing, cleanroom, processing, distribution and storage environments involving products such as vaccines, drugs, blood, biologics etc. One of the Vaisala’s key technologies is the
viewLinc Continuous Monitoring System for research, manufacturing and storage facilities.
The system was designed for highly regulated life science applications such as pharmaceutical warehouses, laboratories, cold rooms, and cleanrooms. By monitoring critical parameters in these spaces, valuable products are preserved and safeguarded for human use. For example, in the new children’s hospital in Helsinki, Finland, the viewLinc system monitors the tissue bank around the clock.
ensuring safeTy
By monitoring critical environments and conditions in healthcare, pharmaceutical, and biotechnology industries, Vaisala solutions are helping to ensure patient and personnel safety as well as the safety and efficacy of medicines and vaccines. These technologies are making a significant contribution to the fight against the COVID-19 pandemic and will continue to help support the United Nations’ Sustainable Development Goals in the future.
Vaisala
www.vaisala.com/en
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