SFA RESEARCH SPRING 2023
Dr. Drayna received his bachelor’s degree from the University of Wisconsin in 1976, and his Ph.D. from Harvard University in 1981, followed by postdoctoral training at the Howard Hughes Medical Institute at the University of Utah. He joined the NIDCD in 1997, focusing on disorders of auditory pitch perception, variation in human taste perception, and disorders of voice and speech. Dr. Drayna’s work has had a major focus on the genetics and neuroscience of stuttering.
in mice. This is only an animal model, and one that has obvious limitations for understanding human speech. Our ZBTB20 findings now provide the first connection in humans between astrocytes and stuttering.”
Mutations in ZBTB20 appear to be a relatively uncommon cause of stuttering. While such mutations occur much more frequently in individuals who stutter compared to the general population (where they are very rare), they are found in less than 1% of individuals who stutter. With a particular cell type of interest to pursue, it is hoped that further progress can be made in understanding stuttering at a highly detailed level within the brain.
Publication/reference: Frigerio-Domingues, C., Raza, M.H., Han, T.-U., Barnes, T., Shaw, P., Sudre, G., Riazuddin, S., Morell, R., and Drayna D. Mutations in ZBTB20 in individuals with persistent stuttering. MedRXive 2022: https://
medrxiv.org/cgi/content/short/2022.11.03.22281471v1
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