EVENT REVIEW
speakers, each looking at cutting edge technology. ‘Moving from whole-slide imaging to no-slide imaging – new futures for pathology’ was the title of the talk by Richard Levenson, Professor and Vice Chair for Strategic Technologies, Pathology Dept at University of California, Davis. He presented a guide to no- slide imaging and new technologies for improved whole-slide imaging. The first new technology examined
was Fluorescence Imitating Brightfield Imaging (FIBI), which is able to produce images from a piece of tissue under glass with a thin layer of stain enhanced by fluorescent light, with Richard showing direct comparisons for diagnosis purposes between a 5-micron slide (preparation time eight hours) and a thick specimen (prep time less than five minutes. Using this method tissue is stored in a modified histology cassette, used for both staining and imaging and subsequent storage / tracking. Using thicker specimens can enable more detail and more information to be contained in the sample, especially blood vessels.
Dual (mode) Emission and
Transmission (DUET) microscopy was also presented. A new method developed in Richard’s own laboratory, it takes existing H&E slides, scans them and creates a digital H&E image and collagen map within two minutes directly from the slide without the need to create a new section. These images are able to highlight previously invisible features, for example collagen fibres that cannot be seen on a bright field image. Also shown was qOBM (quantitative oblique back- illumination microscopy) being developed by Francisco Robles at Georgia Tech, which is able to create images not just slide-free, but stain-free, and in-vivo. Together these three technologies
offer considerable benefits; FIBI provides real-time results that can be interpreted by AI for faster patient care; DUET- enabled whole-slide imaging generates novel information that could enhance
The meeting saw 16 speakers address delegates on subjects including the transformation from whole- slide imaging to no-slide imaging, pathology education, and drone applications for sustainability.
AI performance; while qOBM has the potential for real-time high-resolution (in- vivo) histology Wrapping up the day was Ulysses
Balis, Professor and Director, Division of Pathology Informatics at the University of Michigan Department of Pathology who described his experience of the multi-year project to prepare for and deploy an all-digital pathology workflow at a significant scale. This presentation provided an interesting counterpoint to the earlier focus on NI, and Professor Balis outlined in great detail the considerable preparations made for the project, including planning, motivations, acquisition of both software and hardware along with the layout required for both treatment and teaching facilities. The dual function (teaching and treatment) of Michigan Medicine was key here as the long-term vision needed to serve both students and patients. From the beginning the aim was to avoid the digital pathology infrastructure becoming siloed and fragmented and a centralised approach to image management was needed in order to achieve this, with pathology integrated from the start in
the enterprise imaging platform used at Michigan.
Installing equipment during the roll out was key, with both scanner count and set up of monitors at work stations and teaching stations coming under close scrutiny.
Other speakers
Further subjects at the event included the use of drones in sample transportation with a view to sustainability, GIRFT (Getting it Right First Time) for Total Pathology Delivery, pathology education across the world and a discussion of the ‘value’ of pathology services in the NHS and how it can be measured and interpreted. The second day saw inspirational speaker Cathy O’Dowd address the delegates. A motivational speaker, author, and climber, Cathy was the world’s first woman to climb Mount Everest from both the north and south sides.
Pathology Horizons 2025 will take place in Hobart, Tasmania.
www.pathologyhorizons.com
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