Sepsis treatment
The power of early insight Consensus in the sector and multiple studies reinforce the principle that early intervention in sepsis is critical to survival. A landmark analysis published in the journal, Critical Care Medicine, found that each hour of delay in administering effective antibiotics was associated with a measurable increase in mortality.6
However,
pharmacologic therapy is only one component of early management - fluid and vasopressor support must be equally precise. The NHS England Sepsis Action Plan echoes this need for rapid and accurate assessment, promoting the use of structured escalation and screening tools to improve time-to-treatment.7 Advanced haemodynamic monitoring complements these efforts by providing physiological clarity at the bedside. It means clinicians can distinguish between distributive, hypovolaemic, and cardiogenic shock, ensuring that treatment is not only fast but also appropriate. By identifying instability early and supporting instantaneous evaluation of therapeutic interventions, continuous haemodynamic monitoring can prevent the transition to septic shock and reduces the risk of multi-organ dysfunction. A review in the Journal of Intensive Care concluded that real-time monitoring tools are associated with reduced ICU length of stay, fewer complications, and better fluid stewardship.8
Real-world impact: Croydon University Hospital The implementation of advanced haemodynamic monitoring at Croydon University Hospital illustrates these benefits in practice. The Trust introduced ten Mostcare Up monitors to its 22-bed intensive care unit, reporting both clinical and operational gains. Tim Kuhn, Head of Nursing at the hospital’s Critical Care and Critical Care Outreach Team spearheaded the introduction of the devices in-line with the unit’s philosophy. He said: “Our Critical Care Unit provides a safe and supportive environment in which we care for patients who require specialised nursing and medical care. Our philosophy is based on a commitment to provide physical, psychological and spiritual care for our patients and their families. “We aim to offer medical and nursing care
to the highest standard based on research and best practice guidelines. What’s more, all colleagues who work in the unit are part of a multidisciplinary team, each contributing their skills and knowledge to provide essential support to our patients, who are often the most critically ill individuals in our hospital. “As part of our ITU investment we formed a consultant group to trial Mostcare Up. During
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the trial we noticed how easy the machine was to use – the ‘plug and play’ functionality and data validation without the need for consumables, meant there were clear benefits to using the technology. Once the trial ended we bought ten devices, allowing us to continue to benefit from their ease and efficiency and provide the best care for our patients.” As well as improving decision-making, the
technology delivered financial savings of around £50,000 per year and freed up approximately five hours of clinician time per patient, per week. While the system supports a range of critical conditions, it demonstrates how real-time insight can streamline workflows and support safer, more personalised care. Wider adoption of this technology, especially
in emergency and paediatric settings, could accelerate the detection and treatment of sepsis while helping to alleviate pressures on staff and resources.
The future of sepsis monitoring As healthcare systems grapple with rising demand and workforce pressures, technologies that enhance diagnostic speed and precision are a must-have, not a luxury. Sepsis remains a major cause of morbidity and mortality in the UK. Introducing advanced haemodynamic monitoring into routine practice offers a practical and effective way to improve patient outcomes. From paediatric ICUs to busy emergency departments, real-time monitoring equips healthcare professionals with the insights needed to act quickly, reduce uncertainty, and tailor treatment to each patient’s evolving needs. As the evidence base continues to grow, its adoption could prove a valuable step in the national effort to reduce sepsis mortality and enhance quality of care.CSJ
References 1. The UK Sepsis Trust
https://sepsistrust.org/ wp-content/uploads/2024/07/Sepsis-Manual- 7th-Edition-2024-V1.0.pdf
About the author
James Leek is the Business Manager for Haemodynamic Management at Vygon UK. A seasoned business manager, with two decades of dedicated experience at the company, James has held a diverse range of roles, consistently contributing to Vygon’s success through various capacities. He now leads performance and growth for Vygon’s haemodynamic management portfolio. Vygon is a supplier of medical devices designed to help clinicians deliver the best possible outcomes for their patients.
2. Saugel B, et al. Intra-operative haemodynamic monitoring and management of adults having noncardiac surgery: A statement from the European Society of Anaesthesiology and Intensive Care. Eur J Anaesthesiol. 2025 Jun 1;42(6):543-556. doi: 10.1097/ EJA.0000000000002174. Epub 2025 May 7. PMID: 40308048.
3. Evans L, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/ s00134-021-06506-y.
4. ESAIC (2025). Intra-operative haemodynamic monitoring and management of adults having noncardiac surgery. A statement from the European Society of Anaesthesiology and Intensive Care. EJA.
5. Sepsis Research FEAT 6. Kumar A, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006 Jun;34(6):1589-96. doi: 10.1097/01. CCM.0000217961.75225.E9.
7. NHS England (2023). Sepsis Action Plan. 8. Cecconi M, et al. Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups. Crit Care. 2013 Mar 5;17(2):209. doi: 10.1186/ cc11823
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