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CARDIOLOGY


adolescence is likely to help protect against later heart disease, particularly if people stay fit as they age. Physical activity may also alleviate some of the negative consequences of stress. This is relevant to all adolescents, but those with poorer well-being could benefit from additional support to encourage exercise and to develop strategies to deal with stress.”


Daytime sleeping Scientists also presented findings that drifting off for more than one hour could be risky. 5,1 “Daytime napping is common all over the world and is generally considered a healthy habit,” said study author Dr. Zhe Pan of Guangzhou Medical University, China. “A common view is that napping improves performance and counteracts the negative consequences of ‘sleep debt’. Our study challenges these widely held opinions.” Previous research on the link between daytime naps and death or cardiovascular disease has produced conflicting results. In addition, it did not account for the duration of night-time sleep.


This study summarised the available evidence to assess the relationship between napping and the risks of all-cause death and cardiovascular disease. A total of 313,651 participants from more than 20 studies were included in the analysis. Some 39% of participants took naps.


The analysis found that long naps (more than 60 mins) were associated with a 30% greater risk of all-cause death and 34% higher likelihood of cardiovascular disease compared to no napping. When night-time sleep was taken into account, long naps were linked with an elevated risk of death only in those who slept more than six hours per night.


Rates of in-hospital mortality were significantly lower in patients who received the flu vaccine (1.3%) compared to those who did not receive the flu vaccine (3.6%). Similarly, rates of in-hospital mortality were significantly lower in patients inoculated against pneumonia (1.2%) compared to those who were not inoculated (3.6%).


Overall, naps of any length were linked with a 19% elevated risk of death. The connection was more pronounced in women, who had a 22% greater likelihood of death with napping compared to no napping, and older participants, whose risk rose by 17% with naps. Short naps (less than 60 minutes) were not risky for developing cardiovascular disease. Dr. Pan said: “The results suggest that shorter naps (especially those less than 30 to 45 minutes) might improve heart health in people who sleep insufficiently at night.” The reasons why napping affects the body are still uncertain, said Dr. Pan, but some studies have suggested that long snoozes are linked with higher levels of inflammation, which is risky for heart health and longevity. Other research has connected napping with high blood pressure, diabetes, and poor overall physical health. He concluded: “If you want to take a siesta, our study indicates it’s safest to keep it under an hour. For those of us not in the habit of a daytime slumber, there is no convincing evidence to start.”


Heart attack and gender Other findings included the latest research on gender-related risk factors, including the results of a study which found that women in their 30s and 40s with polycystic ovary syndrome (PCOS) are more likely to get heart disease.6


While women with PCOS are at greater risk, the researchers also highlighted that efforts can be made to mitigate these risks through lifestyle interventions. “Polycystic ovary syndrome isn’t a life sentence – there are many ways to stay heart healthy,” said study author Dr. Clare Oliver-Williams of the University of Cambridge, UK. “Small changes add up, like eating more fruits and vegetables and doing more exercise.”


It is estimated that 6%-20% of women of reproductive age have polycystic ovary syndrome (PCOS).7


Features of the condition


include multiple cysts (fluid-filled sacs) on the ovaries, irregular periods, excess body hair or hair loss from the head due to high levels of male hormones, and difficulty becoming pregnant. Women with PCOS are more likely to be


overweight or obese, have diabetes, and have high blood pressure – all risk factors for heart disease and stroke.


This study examined whether this risky profile translates into a greater likelihood of developing cardiovascular disease – and, for the first time, whether that persists across the lifespan. Dr. Oliver-Williams explained: “Some PCOS symptoms are only present during the reproductive years, so it’s possible that the raised chance of heart disease might disappear later in life.”


The study included 60,574 women receiving treatment to help them get pregnant, such as in vitro fertilisation (IVF), from 1994 to 2015. Of those, 6,149 (10.2%) had PCOS. The researchers used medical records to follow the women for nine years. During that period, 2,925 (4.8%) women developed cardiovascular disease. Overall, women with PCOS were at 19% higher risk of developing cardiovascular disease than women who did not have PCOS.


When divided into age groups, women with PCOS aged 50 and over did not have a


NOVEMBER 2020 WWW.CLINICALSERVICESJOURNAL.COM l 25





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