Blood cultures executive-summary
2 UK Standards for Microbiology Investigations (UK SMI) S 12: sepsis, and other systemic and disseminated infections.
3 Marquet K, Liesenborgs A, Bergs J, Vleugels A, Claes N. Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis. Crit Care. 2015 Feb 16;19(1):63. doi: 10.1186/s13054-015-0795-y.
4 Kadri SS, et al., Inappropriate empirical antibiotic therapy for bloodstream infections based on discordant in-vitro susceptibilities: a retrospective cohort analysis of prevalence, predictors, and mortality risk in US hospitals. Lancet Infect Dis. 2021 Feb;21(2):241-251. doi: 10.1016/S1473-3099(20)30477-1
5 Retamar P et al.,. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agents Chemother. 2012 Jan;56(1):472-8. doi: 10.1128/ AAC.00462-11.
6 Tabah A et al., Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study. Intensive Care Med. 2023 Feb;49(2):178-190. doi: 10.1007/s00134-022- 06944-2.
7 Rhee C et al. Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA Network Open. 2020;3(4):e202899.
8 Arulkumaran N, Routledge M, Schlebusch S, Lipman J, Conway Morris A. Antimicrobial- associated harm in critical care: a narrative review. Intensive Care Med. 2020 Feb;46(2):225- 235. doi: 10.1007/s00134-020-05929-3.
9 Timbrook TT, Morton JB, McConeghy KW, Caffrey AR, Mylonakis E, LaPlante KL. The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017 Jan 1;64(1):15-23. doi: 10.1093/cid/ ciw649.
10 Lamy B, Sundqvist M, Idelevich EA; ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES). Bloodstream infections - Standard and progress in pathogen diagnostics. Clin Microbiol Infect. 2020 Feb;26(2):142-150. doi: 10.1016/
j.cmi.2019.11.017
11 Langford BJ, Nisenbaum R, Brown KA, Chan A, Downing M. Antibiotics: easier to start than to stop? Predictors of antimicrobial stewardship recommendation acceptance. Clin Microbiol Infect. 2020 Dec;26(12):1638-1643. doi: 10.1016/j. cmi.2020.07.048
12 Langford BJ, Daneman N, Leung 46
www.clinicalservicesjournal.com I June 2023
V, Langford DJ, Cognitive bias: how understanding its impact on antibiotic prescribing decisions can help advance antimicrobial stewardship. JAC-Antimicrob. Resist. (2020), p. 2
13 Cairns KA, Doyle JS, Trevillyan JM, Horne K, Stuart RL, Bushett N, Yong MK, Kelley PG, Dooley MJ, Cheng AC. The impact of a multidisciplinary antimicrobial stewardship team on the timeliness of antimicrobial therapy in patients with positive blood cultures: a randomized controlled trial. J Antimicrob Chemother. 2016 Nov;71(11):3276-3283. doi: 10.1093/jac/dkw285.
14 Perez KK, Olsen RJ, Musick WL, Cernoch PL, Davis JR, Land GA, Peterson LE, Musser JM. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch Pathol Lab Med. 2013 Sep;137(9):1247-54. doi: 10.5858/arpa.2012- 0651-OA.
15 Mponponsuo K, Leal J, Spackman E, Somayaji R, Gregson D, Rennert-May E. Mathematical model of the cost-effectiveness of the BioFire FilmArray Blood Culture Identification (BCID) Panel molecular rapid diagnostic test compared with conventional methods for identification of Escherichia coli bloodstream infections. J Antimicrob Chemother. 2022 Feb 2;77(2):507-516. doi: 10.1093/jac/dkab398. PMID: 34734238.
16 Doern GV, Carroll KC, Diekema DJ, Garey KW, Rupp ME, Weinstein MP, Sexton DJ. Practical Guidance for Clinical Microbiology Laboratories: A Comprehensive Update on
the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem. Clin Microbiol Rev. 2019 Oct 30;33(1):e00009-19. doi: 10.1128/CMR.00009-19.
17
https://infectionlearninghub.co.uk/blood- culture-pathways/#
About the author
Dr. Yoann Personne, PhD, is director of Medical Affairs for bioMérieux UK & Ireland. With over six years of experience in the diagnostic industry and a background in academic research, his primary interests lie in infectious diseases and associated diagnostics for optimal patient management and prevention of antimicrobial resistance.
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60
