PVC | PLASTICISERS
ADK Cizer C series are linear or branched trimel- litate plasticisers for PVC applications where high heat resistance, low volatility and flexibility at low temperature is required, such as wire and cable and automotive interior. Its ADK Cizer PN types are polymeric plasticisers offering good oil resistance, anti-migration performance, and low volatility. Targeted applications include hose, cable, gasket and other applications where high oil resistance is a requirement.
Bio-based approval The Santicizer Platinum G-2000 plasticiser from Valtris, an epoxy soyate ester with 85% certified biobased content, has recently gained the US
Department of Agriculture (USDA) Certified Biobased Product label. “Santicizer Platinum G-2000 is an excellent general purpose plasticiser with performance comparable to other non-phtha- late general purpose plasticisers such as DOTP or DINCH,” says Mark Holt, Business Director, Polymer Modifiers at Valtris. Holt says that, along with the significantly bio-based content, the G-2000 grade also offers good processing performance, low temperature properties, and very good heat stability. Formula- tors can combine it with other Santicizer Platinum grades in their recipes. Away from the bioplasticiser sector, Valtris also recently launched Santicizer Platinum P-1800, the
Science and regulatory update
This brief update on some of the latest research into plasticiser safety and snapshot of the current European regulatory position is based on information supplied by European Plasticisers, which is part of the European trade association Cefic.
Plasticiser modelling A scientific project aimed at developing a physiologically-based pharmacoki- netic (PBPK) model for plasticisers was initiated in 2017 by European Plasticis- ers and co-funded by VinylPlus, the sustainability initiative of the PVC value chain. Its objective is to assess the safe use of plasticised PVC and support scientifically-solid risk assessments, rather than those which use in-vitro studies (which the association argues are not representative of the complex metabolism in whole organisms). The project’s first PBPK model for
DINCH was published in a peer- reviewed journal in 2019. A model for DINP was published in August 2020. PBPK models for DEHTP, DPHP, DEHA, DINA and DBA are currently under development and the respective studies will be submitted for publica- tion in scientific journals.
DINP evaluation Last year also saw the publication by the University of Edinburgh in the UK of a study titled: ‘Systematic compari-
32 COMPOUNDING WORLD | August 2021
Global plasticiser consumption data covering the past 25 years shows that low molecular weight phthalates have been substantially replaced by high molecular weight ortho-phthalates and other chemistries that do not fall into the EU category of Substances of Very High Concern (SVHC) Source: CEFIC/IHS
son of the male reproductive tract in foetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming win- dow.’ According to European Plasticis- ers, the study provides evidence on the clear differences between the effects occurring with DBP – a low molecular weight phthalate – and DINP, confirming the latter does not cause adverse reproductive effects and is not an endocrine disruptor.
Risk assessment European Plasticisers says an updated EU risk assessment of the phthalates DBP, BBP, DEHP, DINP and DIDP for
use in food contact materials (FCM) — which concluded that “current exposure to these five phthalates from food is not a concern for public health” — has yet to lead to adoption in the 16th amendment to the Plastic Food Contact Material Regulation. In October 2020, EFSA published “Part 1 of a two-part mandate on a re-evalua- tion of the risks to public health related to the presence of phthalates, structurally similar substances, and replacement substances from food contact materials (FCMs)”. The outcome of this Risk Assessment is expected by end of May 2022. �
www.europeanplasticisers.eu
www.compoundingworld.com
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