markers and their productions are reflecting the level of the inflammation. With the inflammatory challenge, TEER is sig- nificantly decreased vs the negative control, meaning that the tight junctions are altered (Table 1). The addition of the combination of the alkaloids and neo-lignans plants delivers a significant improvement of the intestinal integrity whereas alkaloids alone or neo-lignans did not lead to any improve- ment. In signs of inflammation, basal IL-8 secretion is signifi- cantly increased. The combination of plant extracts decreased the secretion of basal IL-8 proving its ability to limit the over activation of the immune system after an inflammatory chal- lenge where respectively alkaloids or neo-lignans alone were not able to reduce the secretion of basal IL 8. These results as- sess the interest of such patented combination and prove its synergistic effect on the preservation of intestinal integrity avoiding the leaky gut syndrome and on the modulation of the immune response to an inflammatory challenge.
In vivo results The trial’s aim was to evaluate the effect plant extract supple- mentation added in sows and piglet diets. The trial compared the performances of four groups of piglets (total of 624) after weaning. The trial was conducted on three different batches in France. One group of sows (A) received a standard diet, and the second one (B) received the same standard diet plus the plant extracts combination from 15 days before farrowing and until weaning (total of 36 days). Piglets of both sows groups were divided into two groups also one with a stand- ard piglet diet (A1, B1) and a second (A2, B2) with the plant extracts combination from 20 to 67 days of age. All the piglets had similar weights at weaning. The best performances were obtained with the group (B2) of piglets fed with the plant ex- tracts combination in post-weaning and originating from sows fed also with it. ADG of this group of piglets was signifi- cantly improved by 11.4% (P<0.001) compared to ADG of
control group. The two best groups in terms of ADG after weaning are those with the plant extracts combination in lac- tating diet (Figure 1). This improvement of ADG can be ex- plained by a better feed intake and feed efficiency.
Synergistic effects of plant extracts Many types of stresses can trigger inflammation, oxidative stress and immune response, which can cause a lack of performance and profitability. Combining plant extracts with different properties delivers greater benefits from synergies, enabling animals to better face inflammatory and oxidative processes around sensitive and stressful periods. The combination of plant extracts (Powerjet) dedicated to swine, poultry and ruminant acts on the preservation of a gut health by preventing the leaky gut. Thus, better nutrient absorption and use by the animals occurred when they are facing a stress period generating inflammation.
One of the main targets for farmers is to ensure that piglets will eat properly after weaning.
PHOTO: WISIUM
Figure 1 - ADG of piglets in post-weaning from sows fed with or without Powerjet.
A1 - Control in maternity / Control in post-weaning A2 - Control in maternity / Powerjet in post-weaning B1 - Powerjet in maternity / Control in post-weaning B2 - Powerjet in maternity / Powerjet in post-weaning
100 200 300 400 500 600 700 800
0 20-42 days 42-67 days 20-67 days (Global) ▶ GUT HEALTH | DECEMBER 2020 55 628 637 643 666 425 440 446 473
172
194 203 225
ADG (g/day)
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