The benefits of using purified beta glucans
BY JULIANA BUENO, VERÔNICA LISBOA, CARLOS RONCHI AND LUCIANO ROPPA, YESSINERGY
I
f you type the word “Beta Glucans” into Google, in 1 second you will find more than 1.3 million articles talking about the beneficial effects of using these dietary fibres, on human and animal nutrition. In the last decades, beta
glucans have received special attention in human nutrition, mainly for their ability to activate the host's defence mechanisms and for their anti-tumour, anti-inflammatory and hypocholesterolemic effects. Due to the growing interest in functional foods and the new laws that prohibit the use of growth-promoting antibiotics, beta glucans have also become a subject of great relevance for animal nutrition. This interest comes from the fact that they can modulate immunological functions and are also responsible for protecting the animal organism against infections and harmful substances.
What are beta glucans? They are non-digestible fibres that are present in the cell wall of several microorganisms, such as multicellular fungi, yeasts, bacteria, and cereals. Depending on their molecular structure, they are considered a biological response modifier due to its immunomodulatory potential. As it is recognised by specific cell receptors, they have the ability to enhance the host's im- mune response. Its continuous intake reduces the risk of dis- ease in animals. Beta glucans from Saccharomyces cerevisiae (Figure 1) are the most widely studied. This yeast is responsi- ble for the fermentation processes in the production of fuel
Purified beta glucan has a strong modulating effect on the immune system, making the animal more resistant to health challenges. Using purified beta glucans in animal feed can reduce mortality and improve post-vaccine response.
alcohol, breads, and alcoholic beverages.
Not all beta glucans are the same The mechanism of immunomodulation mediated by beta glucan depends on its interaction with immune cells located in the intestine, which recognise it and induce local and sys- temic regulatory responses. In this sense, the structure of beta glucan has a great influence on the immunity process, which includes its molecular structure and purity. That is why not all beta glucans are the same. • The non-purified beta glucan is a component of the cell wall of the yeast Saccharomyces cerevisiae present in prod- ucts marketed for animal nutrition, such as dry, hydrolysed and autolysed yeasts. Its concentration is in average 25% and is present in the form of gluco-mananoproteins.
• The purified beta glucan (GlucanGold) with more than 60% concentration, is obtained through a biotechnological pro- cess of purification of the yeast cell wall. Through this pro- cess, this component is presented in the purest form, free of the bonds with mannan-proteins of the cell wall and its physiological response is much more effective. Figure 1 schematically represents the differences in these struc- tures.
Figure 1 - Saccharomyces cerevisiae cell wall composition.
Saccharomyces cerevisiae
Yeast Cell Wall Mannoproteins
ß-glucans 1,3 and 1,6
membrane Chitin
Cell Protein Source:
www.yes.ind.br ß
ß-glucans 1,3 and 1,6
▶ GUT HEALTH | DECEMBER 2020
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