cytokine), and IL-18 (a pro-inflammatory cytokine) was show, both pro-inflammatory and anti-inflammatory cytokines lead to a balanced immune response: activation but no overstimulation of the immune system (which would result in inflammation). Algae β-(1.3)-glucan offered to piglets enhanced protection of the intestinal wall through a significant (p < 0,05) increase in IgA (Figure 1), IgA’s have long been considered to be the first protective barrier against


  0.5


 0.4 0.3 0.2 0.1 0 IgA 


adhesion and invasion of pathogenic microorganisms to the mucosa. A second approach is to reduce the challenge. Some of the most common options available are acids that are capable of bypassing the stomach. More important than the direct pH effect is the acid anion effect, un-dissociated acids are lipophilic and can diffuse through the lipid fraction of cellular membrane of bacteria and act inside as bacteriostatic and bactericide. Another often considered option to control the bacterial challenge post weaning are plant essential oils, these increase the cell wall permeability for protons and K+ ions. The formation of ion gradient leads to impairment of essential processes and death of the cell. A micro encapsulated synergistic blend of functional acids (Formic and Citric) with encapsulated functional flavour ingredients (Cinnamon, Oregano, Citrus fruits, Thyme, Capsicum), inclusion of this blend of acids and essential oils to piglets post weaning resulted in the reduction of diarrhoea when piglets were challenged with E. coli.


Successful weaning requires holistic approach A holistic approach is needed to wean piglets successfully, now and in the future, a fitter immune system and attention to all areas that impact the piglets is needed.


▶ GUT HEALTH | DECEMBER 2020 45


Weaning is one the most stressful event in a piglets life. A holistic approach is essential to weaning successfully.


PHOTO: CHADIN0


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