HEAL ▶▶▶TH
New rapid protection bird flu vaccine
BY NATALIE BERKHOUT M
any poultry flu vaccines protect birds from seri- ous illness and death but do not prevent them from transmitting the virus. This vaccine, which is still under development, triggers a rapid im-
mune response that protects chickens against signs of dis- ease and reduces the amount of virus that they could pass on, which is a significant factor in halting the spread of bird flu. The vaccine would also be easier and less costly to pro- duce than the traditional flu vaccines made in chicken eggs.
Novel technique vaccine New methods have been developed to enhance the immune response that vaccines produce and reduce the amount of vi- rus that birds shed into the environment. One technique in- volves tagging flu virus proteins with a marker that makes them easier for antigen-presenting cells (APCs) to capture. These immune cells can efficiently process the tagged
An improved poultry influenza vaccine has been developed by researchers from the Pirbright Institute. Poultry World spoke to Professor Munir Iqbal, head of the Avian Influenza Virus group, to more fully understand this vaccine and its potential.
proteins, resulting in a robust and long-lasting antiviral response in chickens.
Faster and stronger immune response For the first time researchers at the Pirbright Institute, Surrey, UK, have shown that tagging the flu virus haemagglutinin (HA) protein and directing it to target a specific protein on the chicken APCs, called CD83, generates faster and stronger immune responses to the H9N2 bird flu strain compared to the current industry standard inactivated virus vaccine. The results revealed that the vaccine was both fast acting and
In the targeted antigen delivery vaccine a flu pro- tein (haemagglu- tinin) is targeted to the receptors on antigen-pre- senting cells (APCs) which produce an im- mune response.
▶ POULTRY WORLD | No. 10, 2021
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ILLUSTRATION: MUNIR IQBAL
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