PARTNER FEATURE ▶▶▶
Managing Salmonella Typhimurium LPS challenge
A fever is the body’s natural response to inflammatory stimuli, such as an infection. Once the immune system recognises the infection – bacterial, viral or parasitic – it triggers a change in the body temperature to heal itself.
BY MARCO REBOLLO, ZINPRO A
fever or inflammatory response can be a two-edged sword. It’s beneficial in that the fever is doing its job to protect the animal, but it can also cause decreas- es in productivity, growth and feed efficiency.
Why? Because the fever response requires nutrients on one side, and it reduces appetite on the other side. Let’s imagine a broiler has three buckets of required nutrients – mainte- nance, growth and muscle development. When inflammation occurs in the form of a fever, the immune system must react and divert nutrients to fight the infection, leaving fewer nu- trients available for maintenance, growth and muscle devel- opment. In an ideal situation, the fever response is rapid and short lived, and nutrient depletion will be minimal. However, if the inflammatory response is slow and extended, then the animal will need to divert additional nutrients from the main- tenance, growth and muscle development buckets to help the immune system fight the infection. Thus, leaving limited nutrients available to support the optimum genetic potential of the animal to grow. In addition, an inflammatory response to an infection or disease can negatively impact feed intake and average daily gain.
Table 1 – Cytokine (IL-1β) concentration for layers receiving the Salmonella Typhimurium challenge
Hours Control 3
12 18 Zinc Sulphate Availa-Zn
70.2 pg/100 µL 72.6 pg/100 µL 81.1 pg/100 µL 81.6 pg/100 µL 64.0 pg/100 µL 50.8 pg/100 µL
▶ POULTRY WORLD | No. 1, 2019
Zinc boosts animal’s ability to respond Trace minerals, such as zinc, are one of the key nutrients that boost an animal’s ability to respond to inflammatory stimu- li. Compared to energy or amino acids, the demands of the immune response are higher for trace minerals than for vir- tually all the other nutrients. And the reason for that is they are co-factors for a lot of the enzymes and protective pro- teins that are produced by the immune system. If producers take care of immunity first, ensuring the animal has the nu- trients needed for a strong initial inflammatory response, then the impact on performance will be limited. Because the animal’s body will not need to spend time and energy fight- ing the infection or pathogen long-term, rather it can get back to doing what it’s intended to do and that is to gain muscle and/or produce eggs.
Zinc & Salmonella Typhimurium LPS A study was conducted to evaluate how layers would re- spond to a Salmonella Typhimurium LPS challenge when fed different forms of zinc. The layers were sorted into two
SOURCE: ZINPRO
PHOTO: ISTOCK
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