even if the latter is considered low, and new evidence highlights that such exposure exists.
Detecting mycotoxins in blood Innovad, in collaboration with the University of Ghent, Bel- gium (UGhent), have conducted research that validated the precise detection of mycotoxins and, their transformed phase I and phase II metabolites, in the bloodstream of animals us- ing a state-of-the-art chromatography-based analytical methodology (LC-MS/MS). This method of detection has now been extended to a broad pool of 29 biomarkers of exposure for chickens and pigs. The validated methodology was used to evaluate the in vivo efficacy of our detoxifier technology, Escent S, with very promising results (see Figure 1). The re- search revealed that Escent S exerted a significant detoxifying ability by reducing systemic exposure of blends of mycotox- ins in both animal species. Although this is of importance it- self, the real breakthrough is the drift away from a simplistic toxin binding approach, since non-polar mycotoxins (such as zearalenone) were also reduced systemically under the influ- ence of Escent S.
A user-friendly service Primary research provides answers, but is of particular impor- tance when it translates to a field tool. The joint research with UGhent has led to Myco-Marker, a novel diagnostic tool that is currently under patent. Myco-Marker has been developed to be deployed as an easy, cheap and user-friendly field ser- vice. The end user needs to just place a small drop of blood on an appropriate paper (FTA) card. Plasma separation is not required and neither do import
restrictions apply and we can receive samples from all over the world
Measuring true exposure to mycotoxins What Myco-Marker offers for the first time to the farmer is the ability to measure the true exposure of animals to mycotox- ins, providing extremely high sensitivity. Namely, the exact quantities circulated systemically within the animal, at any given moment. In Myco-Marker this is combined with the precise analytical detection (again via LC-MS/MS) of key my- cotoxins and their main fungal and plant conjugates in feed. However, at Innovad we are taking things a step further. We aim to correlate the presence of mycotoxins in feed and their actual levels in blood (biomarkers of exposure) with the true impact on animals. To do this, Myco-marker® captures the an- imals’ health picture via a detailed questionnaire. All three el- ements will help us build a database and pull-out meaningful trends in the years ahead.
Stress management programme The Myco-Marker diagnostic service is an integrated part of In- novad’s specialised platform for stress and toxin control. Escent S is a unique technology that helps animals to cope with abiot- ic and biotic stress via a multifaceted, holistic approach. The five modes of action of Escent S are backed-up by in vivo data: 1. Preventing oxidative stress 2. Supporting liver and kidney functions 3. Stimulating the animal’s immunity 4. Triggering biotransformation processes within the liver and detoxification
5. Adsorbing and binding polar (water-soluble) toxins ▶ ALL ABOUT FEED | Volume 28, No. 5, 2020 21
Feed risk assess- ments fail to re- veal the true ex- posure of animals to my- cotoxins. There is a desperately need for com- prehensive tech- nologies with multiple modes of action.
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