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A challenge during modern drug development is overcoming low bioavailability. Recent investigations indicate liposomes demonstrable potential to be used as a drug carrier to solve this issue.
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The study of liposome-drug encapsulation is an expanding field due to their versatility and ease of manipulation in terms of their physiochemical and biophysical properties. Conventional liposomes (representation A) are composed of a lipid bi-layer and liquid core, allowing them to encapsulate hydrophilic and hydrophobic drugs. An example hydrophobic drug is Paclitaxel: a chemotherapeutic agent used to treat cancers.
These types of liposomes are relatively stable at physiological pH, though their contents release under acidic conditions. This has potential in providing targeted anti-cancer therapy, through the lower pH values observed in tumour tissue.
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Ligand-targeted liposomes (illustration C) offer potential for targeted drug delivery, by selectively expressing specific ligands at the site of disease.
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Overall, adaptability is the key advantage associated with liposomes for drug delivery.
In preparation of the desired liposomes, high pressure homogenisation (HPH), is often performed on pre-formed liposomes to produce small unilamellar vesicles. HPH also has the capability to load liposomes with drugs, allowing for a streamlined process.
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Avestin’s range of high pressure homogenisers allow for the combination of homogenisation and extrusion which can reduce the number of cycles required to achieve a desired size distribution, making the process more efficient.
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Many formulations of pH-sensitive liposomes are unstable in the blood; overcome by adding poly-ethylene glycol lipid derivatives to the formulation, to produce PEGylated liposomes/ stealth liposomes (representation B).
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Theranostic liposome systems (representation D) encapsulate a nanosized agent, such as iron-oxide and gold nanoparticles, which is utilised for imaging. Theranostic liposomes can be PEGylated and ligand-targeted to produce a comprehensive diagnostic and therapeutic drug delivery system.
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How the Adaptability of Liposomes Assists in Overcoming Today’s Drug Delivery Challenges Smarter Faster
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