19 Chromatography Easy-to-Use RP Capillary Columns and Emitters Improve High-Resolution LC-MS Analysis
Proteomics, clinical peptides and biopharmaceutical research laboratories performing high throughput, high-performance liquid chromatography (HPLC), or liquid chromatography-mass spectrometry (LC-MS) analysis can now benefit from novel capillary chromatography columns and nano- and capillary emitters, specifically designed for highly sensitive top-down, middle-down analysis. These columns and emitters enable laboratories to achieve high- resolution, low-flow separations for intact proteins, monoclonal antibodies (mAbs) and peptides.
The Thermo Scientific MAbPac Reversed-Phase (RP) Capillary HPLC Column builds upon the separation power and reliability of the proven MAbPac RP chemistry in analytical flow. Together with the new Thermo Scientific EASY-Spray Nano and Capillary Emitters, the temperature-controlled MAbPac column enables maximum reliability and performance, while also providing excellent resolution, long column lifetime and low carry-over. The capillary format of the LC column improves sensitivity, achieving outstanding data results even with smaller sample volumes. The format makes the versatile column ideal for applications such as peptide mapping characterisation and analysis of mAbs fragments, antibody drug conjugates (ADC) and PEGylated proteins.
The MAbPac column is available in a convenient EASY-Spray design, which delivers proven ease-of-use by taking advantage of ‘plug and spray’ to low-flow LC. The standalone MAbPac RP Capillary LC column is designed with double nano viper fitters, positioned on each side of the column, enabling finger-tight grip to easily mount the column onto the system and eliminate dead volume. The nano- and capillary emitters are compatible for use with the Thermo Scientific EASY-Spray source and Thermo Scientific FAIMS Pro source. A simple hardware connection delivers continuous stable spray onto the MS system, enabling better reproducibility and robust nano- and capillary flow into LC-MS systems.
More information online:
ilmt.co/PL/6r5Z 54501pr@reply-direct.com IC Support You Can Count On
With Metrohm IC, support comes as standard. Customer service is an integral part of any successful business - both as a provider and receiver. If something goes wrong, it’s important to have a knowledgeable team that knows your instruments inside and out, to support you, without long waiting times. That’s why Metrohm provide their customers with the high- quality, quick response times, after-hours expertise, training and consultations that they deserve.
Metrohm have got your back with services such as: consulting; application testing, set-up and continued support; installation services; tailored training courses and a variety of workshops;preventative maintenance.
More information online:
ilmt.co/PL/KgOa 54118pr@reply-direct.com High Resolution Chromatography Flowmeter Announced
Testa Analytical Solutions eK has developed a new flowmeter which enables continuous measurement of flow rate without interference in chromatography systems.
Flow rate is one of the most important parameters in any liquid chromatography system, it determines retention time or volume and has by nature a major influence on reproducibility.
Compatible with all HPLC and GPC/SEC solvents, the new Testa flowmeter is conveniently sized and powers itself from a USB connection. A modern PC based app allows continuous recording and storage of the measured flow rates. The current
flow rate is also displayed on the flowmeter’s integral high-resolution OLED Display, allowing easy control of current flow value.
Extraordinary high resolution and wide dynamic range makes the Testa flowmeter the perfect flow monitoring tool for the most demanding HPLC and GPC/SEC systems.
The new high resolution flowmeter is available as an off-the-shelf unit and also can be tailored as an optimised OEM module for chromatography instrument company’s interesting in taking advantage of this exciting new technology.
More information online:
ilmt.co/PL/1JAW 53392pr@reply-direct.com
www.microplates.com/microlute-spe Unique HPLC Columns for Extremely Polar Samples
Cogent Diamond Hydride™ HPLC Columns from Microsolv have a silica-hydride surface similar to other Cogent TYPE-C™ phases, but the uniqueness of Diamond Hydride™ is that they have a very small amount of carbon on the surface that adjusts the hydrophobicity to an important level.
It has been the choice of scientists working in metabolomics, bio-analytical or with LCMS for compounds such as amino acids, organic acids, carbohydrates, and very polar small molecules. Non-polar and polar peptides have been separated in the same run.
An important alternative to HILIC, these columns perform extremely well in Aqueous Normal Phase which uses Acetonitrile and Water but equilibrates very rapidly and the data produced is very precise.
Available in Guard, Analytical or Prep sizes with 100A, 4um or 2.2um particle sizes. More information online:
ilmt.co/PL/Ezzq
53049pr@reply-direct.com
FLOW TOGETHER, PERFORM BETTER Superior controlled flow of samples ensures maximum analyte recovery with even better consistency, specificity and sensitivity.
Take traditional solid phase extraction to a whole new level of perfomance with MicroluteTM
CP. Developed
with the hybrid technololgy to enhance sample preparation workflows where reproducibility and reliability matters.
ENHANCED REPRODUCIBILITY
The solid hybrid technology eliminates resin, flow and packing inconsistencies for greater confidence in results, every time.
MICROLUTETM The New Standard
CP for Solid Phase Extraction
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