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August/September 2011
New GC Autosampler Syringes Deliver Leak-Free Performance
Case Study Documents Cost-Saving API Residual Analysis
Hamilton Company, introduces a new line of syringes for GC (gas chromatography) headspace autosamplers. Designed to work with PAL* COMBI-xt GC headspace autosamplers, which are sold under many brand names, the new syringes feature a unique spring-in- plunger design for leak-free operation.
The spring keeps the PTFE plunger tip against the glass barrel, preventing gaps that can occur with GC temperature fluctuations. The rugged Hamilton syringes demonstrate a long lifetime over a large range of temperatures and gradients. All Hamilton syringes meet stringent requirements for dimensional accuracy, needle length, gauge, tip and lifetime.
The new GC headspace autosampler syringes are offered in six volume/needle gauge combinations. "Our engineers have developed an inventive solution that improves overall GC results," explains Mark Carrier, chromatography market segment manager for Hamilton. “The fact that CTC specifies the Hamilton syringe demonstrates the superiority of our product’s design and performance.”
For more information visit:
www.hamiltoncompany.com
Phenomenex announces the publication of a case study, written by scientists at Pfizer, that demonstrates the results of a new method for residual API (active pharmaceutical ingredient) analysis. This new solution replaces 16 older methods for individual key ingredients, and has delivered cost savings of £320,000 (more than $516,000) per year. The method requires just one UHPLC instrument, using Phenomenex Kinetex®
1.7-micron core-shell columns, to resolve all 16 ingredients in just six minutes. In addition to instrument and time savings, the method uses less solvent, reduces waste disposal costs and frees up lab analysts. The method can be reviewed and /or downloaded at:
http://www.phenomenex.com/info/form/casestudy "High-volume laboratories, such as those in pharmaceutical QC, have an acute need to reduce operating costs and free up resources," explains Jeremy Bierman, brand manager for HPLC products. "The Kinetex core-shell technology allows the development of faster and more efficient analytical methods to deliver significant cost and time savings." The Kinetex 1.7-micron column is the first and only sub-2-micron core-shell UHPLC column on the market and typically delivers efficiency gains of 15 to 20 percent over traditional fully porous sub-2-micron columns. For more information visit:
www.phenomenex.com
GC/MS and LC/MS Instrumentation Selected by the Food and Environment Research Agency (Fera) to Ensure Food Safety
Thermo Fisher Scientific announce that the Food and Environment Research Agency (Fera), an executive agency of the UK Government’s Department for Environment, Food and Rural Affairs (Defra), has selected Thermo Scientific GC-MS and LC-MS systems for accurate, rapid and cost-efficient analysis of food products. Fera currently manages more than 600 research projects, analyzing more than 50,000 plant and food samples a year. It is the National Reference Laboratory for chemicals in food such as mycotoxins, polyaromatic hydrocarbons (PAHs), chemicals from food contact materials, dioxins and polychlorinated biphenyls (PCBs) in food and feed and some pesticides and veterinary drugs. The agency is now using the Thermo Scientific TSQ Quantum GC-MS/MS and Exactive high-performance benchtop LC-MS systems to analyse food, feed, water and air samples for potential contamination. As a result, Fera has benefited from substantial time savings as well as accurate and consistently reliable results. The use of pesticides to protect crops and maintain efficiency of production is commonplace in agriculture. Governments, food producers and food retailers have a public responsibility to ensure that any residues occurring in foods for human consumption are at, or below, statutory maximum residue levels (MRLs). Analytical instrumentation must be capable of testing a wide array of foods for a large number of pesticides at concentrations at or below 0.01 mg/kg in an accurate, rapid and cost-effective manner. Fera selected the TSQ Quantum GC-MS/MS based on the system’s ability to perform targeted screening for low concentrations of pesticide residues in foodstuffs. The high sensitivity and selectivity of the instrument has enabled Fera to efficiently achieve 0.01 mg/kg target reporting limits, providing reliable and consistent results, with almost no repeat analyses required. Fera uses the system in combination with Thermo Scientific Xcalibur software for data processing, resulting in significantly increased throughput. The food testing industry is increasingly turning toward holistic food monitoring, an approach often referred to as profiling or screening. This requires a detailed understanding of what is naturally and normally present in foods so that it is possible to monitor the food chain for abnormalities. To accomplish this, Fera chose the Exactive high performance benchtop LC-MS based on its capacity for high resolution and high mass accuracy, enabling detailed, non-targeted screening of food samples. Another key advantage of selecting the Exactive was the system’s complementarity with nuclear magnetic resonance (NMR) spectroscopy, which is a key technique in Fera’s laboratory. Fera has not only benefited from the system’s capacity to analyse samples with high matrix content, but also its reliability and ease-of-use, all of which have resulted in significant time savings. Data are processed and de-convoluted using the advanced Thermo Scientific SIEVE software, further simplifying the analysis of results.
For more information visit:
www.thermoscientific.com
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