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August/September 2011 Foreword
Welcome to the fifteenth edition of Chromatography Today, an edition which highlights a number of current and developing separation science technologies.
The first four themed articles concentrate on ‘chip based technologies’ an area of growing interest to instrument companies, who are striving to adopt some of the now established microfluidic developments into their next generation of instrumentation.
In the first article by Geoff Gerhardt, manager of the Water’s Instrument Research Group, he looks at microfluidic’s as a base technology for the analytical laboratory.
In a ‘question and answer’ session he describes the early chip developments and Water’s involvement in instrument design (electro kinetic pumps) and technology applications in the proteomic area. He concludes that their main driver has been to improve both the usability of their LC systems, whilst maintaining the UPLC performance, and he views this technology playing an increasing and important role in the next generation of LC/MS ‘analysers’.
In the second article, from Andy de Mello’s group at Imperial, they look at one of the main problem areas for ‘lab on a chip’ technology, that of sample injection. They describe the challenges of obtaining reproducible injections of what are the extremely small volumes used in high efficiency electrophoretic separations. The paper examines the use of ‘droplet injection’ and comments on its potential use in the fields of genomics, metabolomics, proteomics and disease diagnostics.
In a more application based paper Stephan Buckenmaier describes the joint work carried out by Agilent and Sandoz on a ‘workflow solution’ for rapid and fully automated characterisation of Glycans.
The paper describes how the ‘mAb-Glyco Chip’ kit was used with an Agilent Infinity HPLC-Chip/MS system to fully automate the complex and time consuming characterisation of N-Glycans from monoclonal antibodies. So successful was the approach that the analysis and associated data processing can now be completed within 20mins.
The last paper of the series describes the work of Peter Myers group at Liverpool. In what has been a relatively short time Peter has assembled a vibrant group of researchers, looking into a variety of chip based technologies and concepts.
The short paper précis the new and innovative work being carried out on ‘Lab on CD’ with the ultimate aim of this technology being to produce a fully developed ‘point of care’ blood analyser.
The next series of articles look at different separation technologies. Vlad Orlovsky and Yury Zelechonok both from SIELIC Technologies review the evolution of mixed – mode chromatography.
This paper summarises the history, development and benefits of mixed mode columns and with the help of a number of case studies, describes their use in the analysis of amines, amino acids, organic and inorganic acids and complex mixtures.
Most of the papers in this edition have concentrated on LC type separations. The paper from Emma Hollender looks at the often misunderstood technology of head space gas chromatography. In her paper she describes the use of Ionic fluids to increase method sensitivity for the determination of residual solvents. The paper looks into the use of two such fluids as head space solvents and compares the GC response of a variety of ‘residual solvents’ against those obtained using the more conventional solvents such as DMSO and DMA.
I am pleased we have been able to publish this article in Chromatography Today as it the first published article which reflects student work in Industry, and I can announce, that Emma as a result of this paper has been awarded the ‘The Chromatographic Society Student Award’ for 2011.
The final technical report comes from Kevin McHale and Mark Sanders from Thermo
Fisher. They describe the use of on-line sample preparation to speed up the analysis of trace level pharmaceutical and personal care products (PPCP’s) in water.
The paper gives an insight into an alternative approach to EPA Method 1694; using a fast HPLC system with two columns (one for pre concentration and the other for analysis) coupled with high performance LC/MS/MS. In all 67 PPCP’s could be detected down to levels at or below 10ng/l.
As usual the second part of the ‘Foreword’ allows me to report on Chromatographic Society matters.
A full report of our last meeting ‘Advances in Separation Science’ at Novartis is detailed in a separate article in this edition. This meeting was extremely well attended and as can be seen from the photographs, everybody seemed to enjoy both the scientific and social content of the event. What was encouraging was the number of students attending the event for the first time, with many being support by the Societies ‘Student Bursary Scheme’.
The next ‘Chrom Soc’ meeting will be held on the 9th of November at LGC Runcorn and is the biennial meeting on ‘Advances in Gas Chromatography’. We now have a full program with speakers from industry, academia and instrument companies. As with previous events we also are planning to have an instrument exhibition to run alongside the meeting.
Full details will be sent out in the next few weeks or if you are interested please contact me on
alan.handley@lgc.co.uk.
Happy separations Alan.
Next Issue - November/December - Polymer Analysis To be included call us on +44(0)1727 855574 or
info@chromatographytoday.com
Alan Handley - President of the Chromatographic Society
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