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May/June 2011
Triple Quadrupole Mass Spectrometer Offers Unparalleled Detection Speed for UHPLC Systems
enabling data acquisition with up to 500 different channels per second. The improvements to the electronics provide ultra- fast mass spectrum measurement speeds of 15,000 u/sec without sacrificing sensitivity or resolution, and ultra-fast polarity switching (15 msec) for the most information without
To increase lab efficiency, researchers are constantly challenged to detect more target analytes with greater sensitivity in hundreds of samples per day. To meet this challenge, Shimadzu (UK) has developed the LCMS- 8030, which combines the power of triple quadrupole mass spectrometry with unmatched speed to provide the ideal complement to its UHPLC systems.
The LCMS-8030 features ultra-fast multiple reaction monitoring (MRM) transitions,
signal deterioration. Patented UFsweeper®
technology
accelerates ions out of the collision cell by forming a pseudo-potential surface. The result is high-efficiency collision-induced dissociation (CID) and ultra-fast ion transport, reducing the sensitivity losses and cross talk observed on other systems. In addition, higher radio frequency (RF) power capability minimises pauses between each transition.
British Society for Proteome Research group meeting, Cambridge, UK 12-14th July
8th BSPR-EBI MEETING
Wellcome Trust Conference Centre, Cambridge, UK
From the visible to the hidden proteome
Confirmed Speakers:
Tim Hunt, Cambridge Jürgen Cox, Martinsried Kris Gevaert, Ghent Claus Jørgensen, London Martin Larsen, Odense Paola Picotti, Zurich Gil Omenn, Michigan Eric Schirmer, Edinburgh Christian von Mering, Zurich Anthony Whetton, Manchester Peter Jungblut, Berlin
Programme Committee:
Rainer Cramer (University of Reading) Steve Pennington (University College Dublin) Rolf Apweiler (EMBL-EBI) Rob Beynon (University of Liverpool) John Timms (UCL)
Organising Committee:
Rainer Cramer (University of Reading) Mike Dunn (University College Dublin) Henning Hermjakob (EMBL-EBI) Kathryn Lilley (University of Cambridge) David O’Connor (University of Southampton) Chris Sutton (University of Bradford)
For more information go to:
www.bspr.org
8th BSPR symposium in conjunction with the European Bioinformatics Institute (EBI) entitled ‘From the visible to the hidden proteome’ is now open for registration
The meeting will be preceded by a workshop 'New Frontiers in Proteomic Technology' and will be immediately followed by the joint EBI-Wellcome Trust course on Proteomics Bioinformatics.
Defining and quantifying all the proteins in a cell/tissue or organism is one of the current grand challenges in proteomics. The resulting 'proteome maps' would have critical applications in many arenas and would support a completely new view of the protein world. Recent
British Society for Proteome Research European Bioinformatics Institute
developments in technology have allowed increasingly rapid progress towards this goal of whole 'proteome maps' but much more remains to be done if we are to
characterise those proteins that are, so far, recalcitrant to analysis - the 'hidden proteome'.
The meeting will bring together international researchers working in disciplines integral to uncovering the 'hidden proteome' to review progress, consider biological insights gained from such studies, and to prioritize future challenges. The program of the meeting places emphasis on clinical applications including the identification of disease biomarkers and opportunities in current large scale studies such as the Human Proteome Project.
For more details visit
www.bspr.org
Integrated sample prep and LC/MS analysis with Agilent LC MassHunterTM AnalystTM
; AB Sciex ; and ThermoScientificTM XCaliburTM
software is performed using one integrated sequence table in combination with GERSTEL MAESTRO software. Addition of standards, derivatization reagents, or diluents; heating; cooling; mixing; centrifugation; SPE or dispersive SPE is performed followed by sample introduction. Sample Prep is performed in parallel with the ongoing LC-MS/MS analysis using MAESTRO PrepAhead for optimised throughput. Priority samples can be inserted into the running sequence without slowing or halting the workflow. MAESTRO operates independently or integrated with the LC/MS sequence table.
For more information, visit
www.gerstel.com
When coupled with Shimadzu’s Nexera UHPLC, the LCMS-8030 can provide reliable and accurate detection of peaks only one- second wide, maximising UHPLC performance. With a polarity switching time of just 15 msec, ultra-fast triple quadrupole measurement time is now a reality.
The combination of the LCMS-8030 with Nexera also brings together the latest hardware on the same platform. The unified platform provides unmatched qualitative and quantitative analysis, increased productivity, and accelerated workflows for high-throughput analysis. Automated optimisation of analytical conditions for each quantitative target compound, which is the key to high-sensitivity analysis, allows unattended overnight operation. In addition, all software operations are handled seamlessly, reducing PC conflicts and the need for user intervention.
For more information, visit
www.shimadzu.com
Integrated LC/MS Sample Prep
12th-14th July 2011
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