MSA 2022 Awards
Ruud’s recent work has involved addition of in situ high- temperature environmental equipment
for TEMs to allow
observation of material growth and behavior under semicon- ductor processing conditions. Tis has included work with an environmental cell for both wet and dry gaseous chemistry to explore in situ nanoparticle and island growth and coarsening. Tis technology has made significant contributions to in situ electron microscopy over a 20- to 30-year period. Ruud’s contributions to instrumentation stand out as he
has also utilized the new capabilities to create a lasting body of scholarship. Citations of his over 260 publications have been consistent, with more than 500 citations per year for most of his career, culminating in his current h-index of 81 (Google Scholar) and 70 (Web of Science). He has numerous honors and in 2020 was elected to the US National Academy of Engineer- ing. He is the holder of 47 patents and has given over 100 pre- sentations since 2006.
Burton Medal Te Burton Medal honors annually the distinguished con-
tributions to the field of microscopy and microanalysis by a scientist who is less than 40 years of age on January 1st
of the
award year (that is, the awardee to be honored at M&M 2022 cannot have been born earlier than 1982).
Burton Medal in Biological Sciences: Yuan “Kai” He Yuan He received his PhD
Yuan “Kai” He, Associate Professor, Northwestern University
with Ishwar Radhakrishnan at Northwestern University while working on the structure-func- tion analysis of the mammalian Sin3 corepressor complex. He then moved to the University of California at Berkeley to work as a postdoctoral fellow with Dr. Eva Nogales, where he reported the human transcrip- tion pre-initiation complex structure (Nature 2013, and subsequent papers). Yuan is a well-trained structural biolo-
gist with an international reputation. He is now an Associate Professor at Northwestern University and an international leader in the field of the cryo-electron microscopy analysis of chromatin and transcription complexes. Yuan’s contributions have significantly advanced our
knowledge of human Pol II transcription preinitiation com- plex (PIC) assembly and architecture. He has also made exceptional contributions to our understanding of the Pol I and Pol II PICs and to the field of large chromatin remodel- ing complexes and DNA repair. Because his initial work was carried out before the resolution revolution afforded by new detector technology, Yuan devised a visualization and image analysis pipeline that used stepwise redundancy of informa- tion to build a rock-solid set of structures of different stages in the PIC assembly process. Te systematic nature of Yuan’s approach and the quality of his EM work resulted in a robust work with great mechanistic insight that was published as a Nature article in 2013 (
https://doi.org/10.1038/nature11991).
2022 July •
www.microscopy-today.com
Colin Ohpus, Staff Scientist, Law- rence Berkeley National Laboratory
He then extended those results to higher resolution (using direct electron detectors) to obtain the structure of the PIC in four different functional states through the transcription initiation process. Published in Nature in 2016 (https://doi. org/10.1038/nature17970), this work is essential material that has set the standard for complex studies in transcription and beyond. Yuan’s design and implementation of an in vitro reconstitution system for the assembly of human transcrip- tion preinitiation complexes for cryo-EM structure determi- nation has been generalized for the purification and cryo-EM studies of other supramolecular complexes. Dr. He is well- published in top tier journals and is well-funded through vari- ous national and private foundation mechanisms.
Burton Medal in Physical Sciences: Colin Ophus Colin Ophus received his
PhD in Materials Engineering from the University of Alberta while working on nanoscale resonators fabricated from metallic alloys, and model- ling and simulation of poly- crystalline thin film growth. His postdoctoral work was as a Materials Fellow at
the
National Center for Electron Microscopy, Lawrence Berkeley National Laboratory (LBNL), where he worked his way through the ranks and is today
a Staff Scientist in Molecular Foundry at LBNL. Colin’s major contributions are the development of simula-
tion methods for scanning transmission electron microscopy (STEM) and major advances in atomic electron tomography (AET) and 4D-STEM techniques and analyses. As a winner of the DOE Early Career Award, he will lead a new effort in quantum electron microscopy (QEM) that has the potential to revolutionize electron microscopy. His expertise in image simulation and overall understanding of electron scattering has led him to develop new methods of phase-contrast and diffrac- tion imaging, and he has proposed advanced techniques such as QEM. Colin’s publication record is among the strongest in the
field, with over 114 peer-reviewed manuscripts in high-level journals such as Physical Review Letters, Nature Materials, and Nature, as well as technical journals important to the field of electron microscopy such as Microscopy and Microanalysis and Ultramicroscopy. Colin has a long list of invited talks at confer- ences, universities, and national labs. His most recent talks at the annual Microscopy & Microanalysis meetings have become “must see” for many attendees, with standing audience mem- bers lining up outside the room.
Albert Crewe Award Te Albert Crewe Award was initiated to recognize annu-
ally the distinguished contributions to the field of microscopy and microanalysis in the physical sciences of an early career sci- entist, of not more than 6 years’ standing since doctoral gradu- ation, for research performed during this period.
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